An anatomical and connectivity atlas of the marmoset cerebellum

Xihua, Zhu; Yan, Haotian; Zhan, Yafeng; Feng, Furui; Wei, Chuanyao; Yao, Yong‐Gang; Liu, Cirong

doi:10.1016/j.celrep.2023.112480

Cited by 5 publications

(1 citation statement)

References 71 publications

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“…Firstly, the single-neuron tracing data was limited to the PFC of the mouse brain. Although this area presents complex connectional patterns, more comprehensive mappings of the entire mouse brain, as well as primate species 26 , 34 – 36 , are indispensable for a deeper understanding of the anatomical principles of interhemispheric connectivity. Secondly, our single-neuron tracing analysis exposed diverse anatomical connectivity patterns across different cells, implying possible variations in FC within a neuronal population.…”

Section: Discussionmentioning

confidence: 99%

Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity

Fei,

Wu,

Zhao

et al. 2024

Nat Commun

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The corpus callosum, historically considered primarily for homotopic connections, supports many heterotopic connections, indicating complex interhemispheric connectivity. Understanding this complexity is crucial yet challenging due to diverse cell-specific wiring patterns. Here, we utilized public AAV bulk tracing and single-neuron tracing data to delineate the anatomical connection patterns of mouse brains and conducted wide-field calcium imaging to assess functional connectivity across various brain states in male mice. The single-neuron data uncovered complex and dense interconnected patterns, particularly for interhemispheric-heterotopic connections. We proposed a metric “heterogeneity” to quantify the complexity of the connection patterns. Computational modeling of these patterns suggested that the heterogeneity of upstream projections impacted downstream homotopic functional connectivity. Furthermore, higher heterogeneity observed in interhemispheric-heterotopic projections would cause lower strength but higher stability in functional connectivity than their intrahemispheric counterparts. These findings were corroborated by our wide-field functional imaging data, underscoring the important role of heterotopic-projection heterogeneity in interhemispheric communication.

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Section: Discussionmentioning

confidence: 99%

Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity

Fei,

Wu,

Zhao

et al. 2024

Nat Commun

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The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial

Wu,

Tu,

et al. 2024

Neuropsychopharmacol.

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New combinations or alternative therapies for major depressive disorder (MDD) are necessary. Intradermal acupuncture (IA) shows promise but requires further investigation regarding its efficacy, safety, and mechanisms. Conducted across 3 centers from November 2022 to January 2024, our randomized controlled trial included 120 participants with moderate to severe MDD, divided into the selective serotonin reuptake inhibitors (SSRIs), SSRIs plus sham IA (SSRIs + SIA), and SSRIs plus active IA (SSRIs + AIA) groups. Acupuncture groups received 10 sessions over 6 weeks at Shenmen (HT7), Neiguan (PC6), Sanyinjiao (SP6) and Taichong (LR3) bilaterally, followed by a 4-week follow-up. The primary outcome was changes in Hamilton Depression Rating Scale-17 (HAMD-17) scores at week 6. Furthermore, healthy controls (HCs) and MDD patients underwent magnetic resonance imaging (MRI) scans for functional connectivity (FC) analysis. After 6 weeks of treatment, the SSRIs + AIA group showed a greater reduction in HAMD-17 score than the SSRIs + SIA group (MD, −4.9 [CI, −7.6 to −2.2], P < 0.001) and SSRIs group (MD, −5.1 [CI, −7.8 to −2.3], P < 0.001). No serious adverse events occurred. SSRIs + AIA resulted in lower incidences of palpitations (vs.SSRIs + SIA: OR, 0.1% [CI, 0.0–1.0%]; vs. SSRIs: OR, 0.1% [CI, 0.0–0.7%]; P < 0.05), somnolence (vs.SSRIs + SIA: OR, 0.1% [CI, 0.0–0.9%]; vs.SSRIs: OR, 0.1% [CI, 0.0–0.7%]; P < 0.05), and nausea (vs.SSRIs + SIA: OR, 0.1% [CI, 0.0–1.0%]; vs. SSRIs: OR, 0.1% [CI, 0.0–0.9%]; P < 0.05). MDD patients showed abnormal FCs, and IA enhanced FCs between striatum and frontal_inf_tri, and striatum and cerebellum in the MRI study. Overall, IA as adjunctive therapy provides clinical efficacy and safety for MDD, and it may exert antidepressant effects by modulating striatal FCs.

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An Open Access Resource for Marmoset Neuroscientific Apparatus

Rollin,

Papoti,

Bishop

et al. 2024

Preprint

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The use of the common marmoset (Callithrix jacchus) for neuroscientific inquiry has grown precipitously over the past two decades. Despite windfalls of grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases in the marmoset, marmoset-specific apparatus are of sparse availability from commercial vendors and thus are often developed and reside within individual laboratories. Through our collective research efforts, we have designed and vetted myriad designs for awake or anesthetized magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), as well as focused ultrasound (FUS), electrophysiology, optical imaging, surgery, and behavior in marmosets across the age-span. This resource makes these designs openly available, reducing the burden of de novo development across the marmoset field. The computer-aided-design (CAD) files are publicly available through the Marmoset Brain Connectome (MBC) resource (marmosetbrainconnectome.org/apparatus) and include dozens of downloadable CAD assemblies, software and online calculators for marmoset neuroscience. In addition, we make available a variety of vetted touchscreen and task-based fMRI code and stimuli. Here, we highlight the online interface and the development and validation of a few yet unpublished resources: Software to automatically extract the head morphology of a marmoset from a CT and produce a 3D printable helmet for awake neuroimaging, and the design and validation of 8-channel and 14-channel receive arrays for imaging deep structures during anatomical and functional MRI.

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An anatomical and connectivity atlas of the marmoset cerebellum

Cited by 5 publications

References 71 publications

Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity

Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity

The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial

An Open Access Resource for Marmoset Neuroscientific Apparatus

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