An anatomically shaped medial meniscus prosthesis is able to partially restore the contact mechanics of the meniscectomized knee joint

Minnen, Branco S. van; Veen, Albert J. van der; Groes, Sebastiaan A.W. van de; Tienen, T.G. van

doi:10.1186/s40634-022-00531-6

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…It was hypothesized that the failures and poor clinical outcomes were the result of the rigidity of the meniscus prosthesis and its fixation technique [ 58 •, 59 ]. A more flexible device was developed, by removing the reinforcement core and replacing the titanium screws with a PET fixation tape.…”

Section: Total Meniscus Replacementsmentioning

confidence: 99%

“…A more flexible device was developed, by removing the reinforcement core and replacing the titanium screws with a PET fixation tape. This second-generation prosthesis showed promising pre-clinical results, by significantly reducing tibiofemoral contact pressures after meniscectomy [ 59 ]. Last year, a clinical study with 10 patients was initiated and will be expanded with four more patients.…”

Section: Total Meniscus Replacementsmentioning

confidence: 99%

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The Current State of Meniscus Replacements

van Minnen,

van Tienen

2024

Curr Rev Musculoskelet Med

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Purpose of Review The field of meniscus replacement is changing continuously, with new devices emerging and others disappearing from the market. With the current tendency to preserve the knee joint, meniscus implants may become more relevant than ever. The purpose of this review is to provide an overview of the current state of partial and total meniscus replacements that have been developed beyond the academic phase. The available clinical and pre-clinical data is evaluated, and omissions are identified. Recent Findings Recent systematic reviews have shown a lack of homogenous clinical data on the CMI and Actifit meniscal scaffolds, especially regarding long-term performance without concomitant surgical interventions. Clinical studies on the medial total meniscus prostheses NUsurface and Artimis are ongoing, with the NUsurface being several years ahead. New techniques for meniscus replacement are rapidly developing, including the Artimis lateral meniscus prosthesis and the MeniscoFix 3D-printed scaffold. Summary All evaluated clinical studies point towards improved clinical outcomes after implantation of partial and total meniscus replacements. Long-term data on survival and performance is of low quality for CMI and Actifit and is unavailable yet for NUsurface and Artimis. It is of major importance that future research focuses on optimizing fixation methods and identifying the optimal treatment strategy for each patient group. New techniques for total and partial replacement of the medial and lateral meniscus will be followed with interest.

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Section: Total Meniscus Replacementsmentioning

confidence: 99%

Section: Total Meniscus Replacementsmentioning

confidence: 99%

The Current State of Meniscus Replacements

van Minnen,

van Tienen

2024

Curr Rev Musculoskelet Med

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“…Each lamella has two horns, one anterior and one posterior. 3 Each meniscus has an inferiorly inclined surface that is concave on the superior side to match the femoral condyles and flat on the inferior side to match the relatively level tibial plateau.…”

Section: Introductionmentioning

confidence: 99%

Association of Knee Pain in Long Standing and Sitting among University Teachers

Tahir¹,

Maqsood²,

Azhar³

et al. 2023

THJ

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Background: Prolonged sitting and standing raise the load on the knee, thus increasing the risk of knee pain and severity among teachers. Objective: To determine the association of knee pain in long-standing and sitting among school and university teachers. Methods: It was a cross-sectional survey conducted on 185 patients with a history of chronic knee pain. The data was collected from school and university teachers in the private and public sectors. Data were collected from both male and female teachers having knee pain and aged between 27 to 60 years and the patients who have a history of knee osteoarthritis, carcinoma, traumatic injury and wound/infection were excluded from the survey. The categorical variables were evaluated by frequency and percentages, while mean and standard deviation were calculated for continuous variables. The correlation was calculated between knee pain reported by university professors due to long periods of standing or sitting. Results: Out of 185 participants, 111 (60%) were females and 74 (40%) were males, with a mean age of 41.37±11.33. There was a weak positive correlation between knee pain and standing hours, which was statistically significant (r=0.273, n =185, p<0.001). There was a negative correlation between knee pain and sitting hours, (r=-0.160, n=185, p<0.05). Conclusion: This study found that prolonged standing hours may increase knee pain among teachers as compared to prolonged sitting. More standing hours during academic activities tend to increase knee pain while prolonged sitting did not increase that pain. There was a negative correlation between knee pain and sitting hours, and weak positive correlation between knee pain and standing hours, which was statistically significant.

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“…Since 2008 a meniscus prosthesis has been developed as an alternative for the meniscus allograft. The prosthesis is based on mechanical [ 13 , 18 ], finite element modelling [ 6 ], tribology [ 11 ] and animal studies [ 19 ]. These studies led to an anatomical meniscus prosthesis for the medial compartment of the knee.…”

Section: Introductionmentioning

confidence: 99%

The first-generation anatomical medial meniscus prosthesis led to unsatisfactory results: a first-in-human study

Tienen

Minnen²,

Defoort

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose The purpose of this first-in-human study was to evaluate the effect of a polycarbonate anatomical meniscus prosthesis system, including the surgical procedure, on knee pain and describe potential adverse events in patients with post-meniscectomy pain syndrome. Methods Eleven patients with post-meniscectomy pain syndrome and limited underlying cartilage damage were enrolled in the study. Five received a medial polycarbonate urethane meniscus prosthesis which was clicked onto 2 titanium screws fixated at the native horn attachments on the tibia. The KOOS score was planned to be collected at baseline and at 3, 6, 12 and 24 months following the intervention including radiographs at 6, 12 and 24 months. MRI scans were repeated after 12 and 24 months. Results The surgical technique to select an appropriately sized implant and correct positioning of the fixation screws and meniscus prosthesis onto the tibia was demonstrated to be feasible and reproducible. Inclusion stopped after 5 patients because of serious adverse device-related events. All patients reported knee joint stiffness and slight effusion in their knee at 6 months follow-up. In 3 patients the implant was removed because of implant failure and in 1 patient the implant was removed because of persistent pain and extension limitation. In none of the patients did the KOOS score improve in the first 6 months after surgery. However, in the patient who still has the implant in situ, PROMs started to improve 1 year after surgery and this improvement continued through 2 years of follow-up. The KOOS Pain, symptoms and ADL were close to the maximal 100 points. KOOS QoL and sport did improve but remained suboptimal. Conclusion This first version of the meniscus prosthesis led to impaired knee function and failed in four out of five patients. The patients where the prosthesis was removed were salvable and the PROMs returned to pre-study levels. The results in the patient where the device is still in place are promising. Level of evidence Level II.

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An anatomically shaped medial meniscus prosthesis is able to partially restore the contact mechanics of the meniscectomized knee joint

Cited by 7 publications

References 32 publications

The Current State of Meniscus Replacements

The Current State of Meniscus Replacements

Association of Knee Pain in Long Standing and Sitting among University Teachers

The first-generation anatomical medial meniscus prosthesis led to unsatisfactory results: a first-in-human study

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