An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men

Schuster, Herbert; Wienker, Thomas F.; Stremmler, Uta; Noll, Bernd; Steinmetz, Armin; Luft, Friedrich C.

doi:10.1016/s0002-9149(99)80164-7

Cited by 47 publications

(24 citation statements)

References 8 publications

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“…More recently, Gardemann et al (1995) found no difference in D-allele frequency among patients with single-, double-, or triplevessel disease. In some case-control studies, patients were characterized according to the presence of angiographically defined CAD (Beohar et al 1995;Friedl et al 1995;Ishigami et al 1995;Kamitani et al 1995;Katsuya et al 1995;Schuster et al 1995;Winkelmann et al 1996), but no analysis between the severity or extent of the coronary lesions and any of these RAS genetic polymorphisms was mentioned.…”

Section: Discussionmentioning

confidence: 99%

“…The best-documented of these is the insertion/deletion (I/D) polymorphism of the ACE gene, which explains most of the genetic variance in plasma ACE levels (Rigat et al 1990). After the initial work of Cambien et al (1992), who first suggested the potential role of the ACE D allele as an independent risk factor for MI, other case-control studies either confirmed (Nakai et al 1994;Beohar et al 1995;Kamitani et al 1995;Schuster et al 1995) or were in disagreement with (Bohn et al 1993;Miettinen et al 1994;Friedl et al 1995;Katsuya et al 1995;Winkelmann et al 1996) their findings, which were further disputed by the results of one large-cohort study (Lindpaintner et al 1995). The common M235T variant of the angiotensinogen (AGT) gene has also been associated with MI in Caucasian (Friedl et al 1995) and Japanese (Ishigami et al 1995;Kamitani et al 1995) individuals, although this association was not observed in the ECTIM study (Tiret et al 1995).…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study

et al. 1996

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Genetic polymorphisms of the renin-angiotensin system (RAS) have been associated with coronary artery disease (CAD) but no relation between these polymorphisms and coronary atherosclerosis has yet been systematically evaluated. The CORGENE study is a cross-sectional study involving 463 Caucasians who underwent standardized coronary angiography for established or suspected CAD [156 patients with a previous myocardial infarction (MI), 307 without MI]. Four angiographic scores assessing the extent and severity of the coronary lesions were obtained from a double visual analysis of each angiogram, arbitration being achieved by a quantitative measurement. Three different genotypes were analyzed: the angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism, the Met to Thr change at position 235 of the angiotensinogen gene (AGT M235T) and the A to C transition at position 1166 of the angiotensin II type-1 receptor gene (AT1R A1166C). No significant association was observed between these polymorphisms and the clinical characteristics of MI and non-MI subjects. While most classical risk factors were positively correlated with the angiographic scores, no significant relationship could be established with the three genotypes (r ranging from -0.08 to 0.05). Only one significant correlation was observed: between the presence of the AGT 235T allele and the extent of the coronary lesions (r = -0.19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study

et al. 1996

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“…In Argentinien solI derzeit das familiare Auftreten als unabhangiger Risikofaktor mit 14% der Infarkte bei Mannern und 26% bei Frauen korreliert sein (CIRUZ-ZI et al 1997 ARBUSTINI et al 1995).Fiir die landliche Bevolkerung in der Umgebung von Marburg/Lahn fand sich diese Assoziation aber nur fiir Frauen (SCHUSTER et al 1995). Zu einem negativen Ergebnis kamen WINKELMANN et aI.…”

Section: Familhire Haufung Genetikunclassified

Durchblutungsstörungen des Myokard

Hort¹,

Arnold²,

Frenzel³

2000

Pathologie Des Endokard, Der Kranzarterien Und Des Myokard

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“…Angiotensin converting enzyme (ACE) is a key component of RAS. The ACE insertion/deletion (I/D) gene polymorphism, which comprises a 287-bp fragment placed within the intron 16 region of the ACE gene, has been identified in different clinical cases such as acute myocardial infarction, cardiac hypertrophy, and failure (Schuster et al, 1995;Holmer and Schunkert, 1996). Presence of the D allele has been associated with increased circulating levels of the ACE enzyme; it has been shown that individuals carrying the DD, ID, and II genotypes have the highest, intermediate, and lowest circulating levels of ACE, respectively.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population

Ayada¹,

Toru²,

Genç³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction that occurs as a result of the normal inflammatory process to protect against harmful irritants and chemicals. Another physiological regulatory process, the renin angiotensin system (RAS), plays an important role in the pathology of many diseases. Angiotensin converting enzyme (ACE) is a key enzyme of RAS. We investigated the frequency of the ACE gene I/D polymorphism in patients with COPD in Turkey. This study was performed on 47 unrelated patients with COPD and 64 healthy subjects. DNA samples were isolated from peripheral blood, and ACE DNA was amplified by polymerase chain reaction. The frequencies of ACE genotypes were 27.7, 55.3, and 17% for DD, ID, and II in the COPD group, respectively, and 43.8, 43.8, and 12.4% in the control group. There was no statistically significant difference between groups (c 2 = 3.078; df = 2; P = 0.220). The distributions of ACE gene D alleles were 38.2% (N = 52) in the COPD group and 61.8% (N = 84) in the control group; and those of I alleles were 48.8% (N = 42) in the COPD group and 51.2% (N = 44) in the control group. There was no statistically significant difference between groups for allele frequency (c 2 = 2.419; df = 2; P = 0.120). We believe these results can be useful for large-scale population genetic research considering the frequency of the ACE gene variation in COPD patients in the Turkish population.

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An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men

Cited by 47 publications

References 8 publications

Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study

Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study

Durchblutungsstörungen des Myokard

Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population

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