An animal study of c.p. titanium screws with different surface topographies

Wennerberg, Ann; Albrektsson, Tomas; Andersson, Bo

doi:10.1007/bf00120275

Cited by 94 publications

(73 citation statements)

References 9 publications

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“…surface topography affects the ty (Buser et al 1991;Wennerberg et al 1995aWennerberg et al , 1995bWennerberg et al , 1996. In a recent study, Gotfredsen et al (1995) even claimed that a rough surface is a pre requisite for the successful implantation in bone of low quality or quantity.…”

Section: Initial Interfacial Healing and Ca-p Coated Oral Implantsmentioning

confidence: 99%

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Hulshoff

Jansen

1997

Clinical Oral Implants Res

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The bone response to different calcium phosphate (Ca‐P) coated and non‐coated titanium implants was evaluated in a goat animal model. Two types of Ca‐P coatings have been investigated: an experimental plasma‐spray bi‐layered Ca‐P coating (FA‐HA) and an amorphous RF magnetron sputter coating (Ca‐P‐a). Fifty‐four conical screw shaped implants were inserted in the lateral and medial femoral condyles of 18 Saanen goats. After implantation periods of 3, 12 and 24 days, the bone‐implant interface was evaluated histologically and histomorphometrically. Light microscopical evaluation revealed that bone formation on the Ca‐P coated implants proceeded faster. At 24 days higher percentages of bone contact were measured for both Ca‐P coated implants than for non‐coated implants. However, this difference was only significant for the FA‐HA coated implants. On basis of these findings. we concluded that Ca‐P coatings show improved bone response due to an initial difference in bone cell response.

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Section: Initial Interfacial Healing and Ca-p Coated Oral Implantsmentioning

confidence: 99%

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Hulshoff

Jansen

1997

Clinical Oral Implants Res

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“…According to Triplet et al (2003) most of the papers have described the dental implants surface as smooth (Sa ≤ 1.0 μm) or rough (Sa > 1.0 μm), although other terms, such as porous, minimally rough (0.5-l.0 μm), intermediately rough (1-2.0 μm), and rough (2-3.0 μm) have also been proposed (Wennerberg et al, 1995).…”

Section: Microarchitecturementioning

confidence: 99%

An Overview Regarding Contemporary Biomechanical Aspects on Immediate Loading Dental Implants

Reis¹,

Pinelli²,

Neto³

et al. 2011

Implant Dentistry - A Rapidly Evolving Practice

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“…2,3 Surface engineering with advanced technologies, including the incorporation of nanotopography, can be used to mimic the natural repair process of the human body, because these surface topographic features on the nanoscale may resemble the natural extracellular matrix in which cells reside and interact. 4 It is therefore hypothesized that nanoscale topographic surface cues can be tailored to regulate cell function in much the same way as the extracellular matrix regulates cell function.…”

Section: Introductionmentioning

confidence: 99%

In vitro proliferation and osteogenic differentiation of mesenchymal stem cells on nanoporous alumina

Song¹,

Ju²,

Song³

et al. 2013

IJN

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Cell adhesion, migration, and proliferation are significantly affected by the surface topography of the substrates on which the cells are cultured. Alumina is one of the most popular implant materials used in orthopedics, but few data are available concerning the cellular responses of mesenchymal stem cells (MSCs) grown on nanoporous structures. MSCs were cultured on smooth alumina substrates and nanoporous alumina substrates to investigate the interaction between surface topographies of nanoporous alumina and cellular behavior. Nanoporous alumina substrates with pore sizes of 20 nm and 100 nm were used to evaluate the effect of pore size on MSCs as measured by proliferation, morphology, expression of integrin β1, and osteogenic differentiation. An MTT assay was used to measure cell viability of MSCs on different substrates, and determined that cell viability decreased with increasing pore size. Scanning electron microscopy was used to investigate the effect of pore size on cell morphology. Extremely elongated cells and prominent cell membrane protrusions were observed in cells cultured on alumina with the larger pore size. The expression of integrin β1 was enhanced in MSCs cultured on porous alumina, revealing that porous alumina substrates were more favorable for cell growth than smooth alumina substrates. Higher levels of osteoblastic differentiation markers such as alkaline phosphatase, osteocalcin, and mineralization were detected in cells cultured on alumina with 100 nm pores compared with cells cultured on alumina with either 20 nm pores or smooth alumina. This work demonstrates that cellular behavior is affected by variation in pore size, providing new insight into the potential application of this novel biocompatible material for the developing field of tissue engineering.

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An animal study of c.p. titanium screws with different surface topographies

Cited by 94 publications

References 9 publications

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

An Overview Regarding Contemporary Biomechanical Aspects on Immediate Loading Dental Implants

In vitro proliferation and osteogenic differentiation of mesenchymal stem cells on nanoporous alumina

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