Support for nature-based solutions (NbS) has grown significantly in the last 5 years. At the same time, recognition for the role of Indigenous Peoples in advancing ‘life-enhancing’ climate solutions has also increased. Despite this rapid growth, the exploration of the intersection of NbS and Indigenous Peoples has been much slower, as questions remain about the ability of NbS to be implemented while respecting Indigenous rights, governance, and knowledge systems, including in their conceptualizations. To address this knowledge gap, we draw on 17 conversational interviews with Indigenous leaders, including youth, women, technicians, and knowledge keepers from what is currently known as Canada to explore Indigenous conceptualizations of nature, nature-based solutions, and the joint biodiversity and climate crisis. Three drivers of the biodiversity and climate crisis were identified: structural legacy of colonization and capitalism, a problem of human values, and climate change as a cumulative impact from industrial disturbances. Building on this understanding, our findings indicate that shifting towards Indigenous conceptualizations of NbS as systems of reciprocal relationships would: challenge the dichotomization of humans and nature; emphasize the inseparability of land, water, and identity; internalize the principle of humility and responsibility; and invest in the revitalization of Indigenous knowledge systems. As the first exploration of Indigenous conceptualizations of nature within NbS literatures, we close with four reflections for academics, advocates, leaders, activists, and policymakers to uplift Indigenous climate solutions for a just, equitable, and resilient future.