An anti-inflammatory dietary intervention to reduce breast cancer recurrence risk: Study design and baseline data

Ramirez, Amelie G.; Parma, Dorothy Long; Muñoz, Edgar; Mendoza, Kristin D.; Harb, Crystel; Holden, Alan E.C.; Wargovich, Michael J.

doi:10.1016/j.cct.2017.03.009

Cited by 19 publications

(57 citation statements)

References 32 publications

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“…Additionally, IL-4 level is high in breast cancer patients who died from ER − /PR − tumors [31]. These data suggest IRISOE TNBC tumor cells secrete inflammatory factors with cancer growth and progression promoting roles [32]. We elected to evaluate in detail the role of IL-6 in IRISOE TNBC tumor aggressiveness.…”

Section: Resultsmentioning

confidence: 99%

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

et al. 2019

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Background To evaluate the cross-talk between BRCA1-IRIS (IRIS)-overexpressing (IRISOE) TNBC cells and tumor-resident mesenchymal stem cells (MSCs) that triggers the aggressiveness or elimination of IRISOE TNBC tumors. Methods We analyzed the effect of silencing or inactivating IRIS on the bi-directional interaction between IRISOE TNBC cells and MSCs on tumor formation and progression. We analyzed the downstream signaling in MSCs induced by IL-6 secreted from IRISOE TNBC cells. We compared the effect of MSCs on the formation and progression of IRIS-proficient and deficient-TNBC cells/tumors using in vitro and in vivo models. Finally, we analyzed the association between IL-6, PTGER2, and PTGER4 overexpression and breast cancer subtype; hormone receptor status; and distant metastasis-free or overall survival. Results We show high-level IL-6 secreted from IRISOE TNBC cells that enhances expression of its receptor (IL-6R) in MSCs, their proliferation, and migration toward IRISOE, in vitro, and recruitment into IRISOE TNBC tumors, in vivo. In serum-free medium, recombinant IL-6 and the IL-6-rich IRISOE TNBC cell condition media (CM) decreased STAT3 Y705 phosphorylation (p-STAT3 Y705 ) in MSCs. Inhibiting IRIS expression or activity prolonged STAT3 Y705 phosphorylation in MSCs. The interaction with IRISOE TNBC cells skewed MSC differentiation toward prostaglandin E 2 (PGE 2 )-secreting pro-aggressiveness cancer-associated fibroblasts (CAFs). Accordingly, co-injecting human or mouse MSCs with IRISOE TNBC tumor cells promoted the formation of aggressive mammary tumors, high circulating IL-6 and PGE 2 levels, and reduced overall survival. In contrast, IRIS-silenced or inactivated cells showed reduced tumor formation ability, limited MSC recruitment into tumors, reduced circulating IL-6 and PGE 2 levels, and prolonged overall survival. A positive correlation between IL-6, PTGER2, and PTGER4 expression and basal phenotype; ER-negativity; distant metastasis-free and overall survival in basal; or BRCA mutant carriers was observed. Finally, the bi-directional interaction with MSCs triggered death rather than growth of IRIS-silenced TNBC cells, in vitro and in vivo. Conclusions The IL-6/PGE 2 -positive feedback loop between IRISOE TNBC tumor cells and MSCs enhances tumor aggressiveness. Inhibiting IRIS expression limits TNBC tumor growth and progression through an MSC-induced death of IRIS-silenced/inactivated TNBC cells. Electronic supplementary material The online version of this article (10.1186/s13058-019-1131-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

et al. 2019

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“…The randomized controlled trial on which this analysis was based has been previously described [23]. Briefly, we recruited 153 overweight and obese (BMI ≥25 kg/m 2 ), early-stage (0-III), English-speaking breast cancer survivors who had completed treatment at least 2 months prior to study enrollment.…”

Section: Methodsmentioning

confidence: 99%

“…At baseline and 6 months, participants completed questionnaires to assess adherence to the Mediterranean diet [6] and spice and herb consumption [23]. The Mediterranean diet assessment tool consisted of 14 questions that were coded one for an answer in agreement with a Mediterranean diet and zero for nonadherence.…”

Section: Methodsmentioning

confidence: 99%

Dietary intervention among breast cancer survivors increased adherence to a Mediterranean-style, anti-inflammatory dietary pattern: the Rx for Better Breast Health Randomized Controlled Trial

Zuniga

Parma

Muñoz

et al. 2018

Breast Cancer Res Treat

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Purpose: The goal of this education and culinary-based dietary intervention was to increase adherence to a Mediterranean-style, anti-inflammatory dietary pattern in breast cancer survivors (BCS) by promoting consumption of anti-inflammatory foods, herbs, and spices. Methods: Overweight and obese, early-stage, BCS were randomized to the Intervention (n=76) or Control (n=77). The six-month intervention included monthly nutrition and cooking workshops, Motivational Interviewing telephone calls and individualized newsletters. Control participants received monthly informational brochures and no navigational services. Dietary intakes were collected via questionnaire and 3-day food records at baseline and 6 months. Results: One hundred twenty-five BCS (n=60 I; n=65 C) completed post-testing (81.7%) and were included in analyses. Adherence to Mediterranean diet guidelines significantly increased in the intervention group, but not in the control group (+22.5% vs. +2.7%, P <0.001). Upon further analysis of adherence to individual dietary guidelines, the intervention group significantly improved adherence to only three guidelines: consuming ≥ 3 servings of fish or shellfish/week, reducing red meat intake to <1 serving/day, and limiting consumption of commercial sweets and baked goods to <3 times/week. The intervention arm increased the use of spices and herbs compared to control (+146.2% vs. +33.3%, P <0.001), including significantly more frequent consumption of cinnamon, turmeric, garlic, ginger, black pepper, and rosemary. Conclusion: An education and culinary-based intervention in BCS successfully increased adherence to a more Mediterranean-style, anti-inflammatory dietary pattern by increasing consumption of antiinflammatory foods, spices and herbs and decreasing consumption of pro-inflammatory foods.

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“…We adapted this model for our local BCS population and smaller study size. We also modified the Patient Navigation approach to one found successful in previous small studies 29,37‐39 …”

Section: Introductionmentioning

confidence: 99%

Quality of life outcomes from a randomized controlled trial of patient navigation in Latina breast cancer survivors

et al. 2020

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Introduction Breast cancer survivorship is a life‐long process involving challenges to health‐care communities and individuals, especially Latinas. Patient Navigation has shown some success in meeting these challenges. The purpose of this study was to compare the effects of an enhanced Patient Navigation program (Intervention; PN+) vs Control (PN) over time on general cancer and breast cancer‐specific quality of life (QoL) in Latina breast cancer survivors (BCS). Methods We conducted a 2‐year, two‐arm randomized controlled trial of the “Staying Healthy” program among Latina BCS. The design compared PN+ vs PN over time. We recruited 60 patients into each study arm and randomized them by sequential numerical assignment. PN+ participants received culturally tailored educational materials and active, personalized Patient Navigation services, including phone calls, transportation, and care coordination. PN participants were navigated only upon request. Primary outcomes included general cancer (Functional Assessments of Cancer Therapy [FACTS]‐G) and breast cancer‐specific (FACT‐B) QoL. Results PN+ participants had significantly improved QoL measures compared to PN at 6‐month follow‐up on all subscales (P‐values .007‐.04) except physical well‐being (PWB; P = .11). Intervention effect size coefficient (standard error) for FACT‐G overall was 7.9 (3.1); P = .01. For FACT‐B, it was 10.9 (3.9); P = .006. Again, all subscales showed significant effects [range 1.7‐3.1 (0.8‐1.2); P‐values .006‐.04], except for PWB [1.5 (1.0); P = .16] and social/family well‐being (SWB) [2.1 (1.1); P = .06]. There were no differences between groups at baseline. Discussion Multiple cultural, psychosocial, and socioeconomic variables contributing to these intervention effects will be addressed in future studies. As the national BCS population continues to increase, more Patient Navigation‐focused partnerships among patients, health‐care professionals, research groups, and community organizations are needed to improve BCS experiences. The Staying Healthy program has the potential to serve as a national survivorship care model for improving Latina BCS QoL.

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An anti-inflammatory dietary intervention to reduce breast cancer recurrence risk: Study design and baseline data

Cited by 19 publications

References 32 publications

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

Dietary intervention among breast cancer survivors increased adherence to a Mediterranean-style, anti-inflammatory dietary pattern: the Rx for Better Breast Health Randomized Controlled Trial

Quality of life outcomes from a randomized controlled trial of patient navigation in Latina breast cancer survivors

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