An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: Taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1β-mediated NFκB activation

Kang-hyun, Joo; Lee, You-Na; Choi, Dea-Kyu; Han, Jeongoh; Hong, Sungchae; Kim, Young Mi; Jung, Yunjin

doi:10.1016/j.ejphar.2009.07.009

Cited by 23 publications

(21 citation statements)

References 25 publications

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“…Taurine has been shown to down-regulate systemic inflammation in acute trauma, sepsis and other immune-deficient conditions in nonpregnant subjects [40]. Furthermore, the chlorinated form of taurine inhibits the production of proinflammatory mediators in innate immune cells via the nuclear factor-κB signaling pathway [41][42][43]. It is therefore possible that the beneficial effects on maternal metabolic parameters may be attributed to the anti-inflammatory actions of taurine.…”

Section: Discussionmentioning

confidence: 93%

Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring

Reynolds

Sloboda

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 93%

Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring

Reynolds

Sloboda

et al. 2015

The Journal of Nutritional Biochemistry

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“…Previous studies have reported that taurine treatment significantly reduces the secretion of the aforementioned proinflammatory cytokines and the expression of the IL-1β, IL-6, TNF-α, GM-CSF, IL-12 and p40 genes (31,32). At concentrations of 2.5, 5 and 10 mg/ml, taurine inhibits the collagen matrix invasion of B16F-10 melanoma cells in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Effects of simvastatin and taurine on delayed cerebral vasospasm following subarachnoid hemorrhage in rabbits

Lin

Zhao

Wan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of the current study was to observe the effects of simvastatin and taurine on delayed cerebral vasospasm (DCVS) following experimental subarachnoid hemorrhage (SAH) in rabbits. A total of 48 New Zealand white rabbits were allocated at random into four groups (control, SAH, SAH + simvastatin and SAH + taurine groups; n=12 each). The rabbit model of DCVS was established using a double hemorrhage method, which involved injecting autologous arterial blood into the cisterna magna in the SAH groups. The SAH + simvastatin group was administered oral simvastatin (5 mg/kg) daily between days 0-6. The SAH + taurine group was administered oral taurine (50 mg/kg) daily between days 0-6. Starch (50 mg/kg) was administered orally to the animals in the other two groups (control and SAH groups). The control group were not subjected to any other injections or treatment. The internal diameter and internal diameter/wall thickness of the basilar artery (BA) were measured. The expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were determined using immunohistochemical and quantitative polymerase chain reaction methods following the sacrifice of all animals on day 7. The activity of nuclear factor (NF)-κB in the BA was also measured using an electrophoretic mobility shift assay. The BA walls in the SAH + simv astatin and SAH + taurine groups exhibited reduced narrowing and corrugation of the tunica elastica interna compared with the SAH group. At the protein and cDNA levels, it was found that cerebral vasospasm of the BA in the SAH + simvastatin and SAH + taurine groups was allevi ated, as indicated by the reduced expression of TNF-α, IL-1β, IL-6 and NF-κB compared with the SAH group (P<0.05). In conclusion, simvastatin and taurine reduced DCVS following SAH in rabbits, which suggests that these compounds may exert anti-inflammatory effects.

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“…Tau is regarded as an antioxidant and membrane stabilizer against oxidative stress and inflammation by inhibiting chemokine secretion from intestinal cells [85, 86]. Moreover, the cellular metabolite taurine chloramine of Tau in the rectal shows anti-inflammatory property on IBD via inhibition on NF- κ B activity [44, 87]. Tau treatment exerts beneficial effects in rats with 2,4,6-trinitrobenzene sulphonic acid- (TNBS-) induced colitis with decreasing inflammatory reactions and apoptosis [88].…”

Section: Amino Acids: Application In Inflammatory Bowel Disease Thmentioning

confidence: 99%

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

Bao

Feng

Yao³

et al. 2017

Mediators of Inflammation

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Inflammatory Bowel Disease (IBD) is a kind of chronic inflammation, which has increasing incidence and prevalence in recent years. IBD mainly divides into Crohn's disease (CD) and ulcerative colitis (UC). It is hard to cure IBD completely, and novel therapies are urgently needed. Amino acids (AAs) and their metabolites are regarded as important nutrients for humans and animals and also play an important role in IBD amelioration. In the present study, the potential protective effects of AAs and their metabolites on IBD had been summarized with the objective to provide insights into IBD moderating using dietary AAs and their metabolites as a potential adjuvant therapy.

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An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: Taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1β-mediated NFκB activation

Cited by 23 publications

References 25 publications

Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring

Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring

Effects of simvastatin and taurine on delayed cerebral vasospasm following subarachnoid hemorrhage in rabbits

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

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