An antibiotic amnesty can be a One Health tool to tackle antimicrobial resistance

Allerton, Fergus; Jamieson, Conor; Aggarwal, Rakhi; Barker, Angela; Work, Megan; Cooper, Donna; Ramsey, Ian

doi:10.1038/s41591-023-02334-3

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Last but not least, awareness campaigns [70,71], surveys [72], and technological integration in work [73,74] and learning [75,76] environments are crucial to stop an otherwise announced disastrous, unstoppable plague: communication is the key to unified, efficacious actions, especially when the enemy to defeat is so protean, diffused, and challenging.…”

Section: Polymixinsmentioning

confidence: 99%

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Nicolosi,

Petronio Petronio,

Russo

et al. 2023

IJMS

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The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains, usually associated with poorer patient outcomes and higher costs. In order to preserve the usefulness of these life-saving drugs, it is crucial to use them appropriately, as also recommended by the WHO. Moreover, innovative, safe, and more effective approaches are being investigated, aiming to revise drug treatments to improve their pharmacokinetics and distribution and to reduce the onset of drug resistance. Globally, to reduce the burden of antimicrobial resistance (AMR), guidelines and indications have been developed over time, aimed at narrowing the use and diminishing the environmental spread of these life-saving molecules by optimizing prescriptions, dosage, and times of use, as well as investing resources into obtaining innovative formulations with better pharmacokinetics, pharmacodynamics, and therapeutic results. This has led to the development of new nano-formulations as drug delivery vehicles, characterized by unique structural properties, biocompatible natures, and targeted activities such as state-of-the-art phospholipid particles generally grouped as liposomes, virosomes, and functionalized exosomes, which represent an attractive and innovative delivery approach. Liposomes and virosomes are chemically synthesized carriers that utilize phospholipids whose nature is predetermined based on their use, with a long track record as drug delivery systems. Exosomes are vesicles naturally released by cells, which utilize the lipids present in their cellular membranes only, and therefore, are highly biocompatible, with investigations as a delivery system having a more recent origin. This review will summarize the state of the art on microvesicle research, liposomes, virosomes, and exosomes, as useful and effective tools to tackle the threat of antibiotic resistance.

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