An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota

Lai, Yongkang; Zhang, Tinglin; Yin, Xiaojing; Zhu, Chunping; Du, Yiqi; Li, Zhaoshen; Gao, Jie

doi:10.1016/j.apsb.2024.03.014

Acta Pharmaceutica Sinica B

2024

DOI: 10.1016/j.apsb.2024.03.014

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An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota

Yongkang Lai,

Tinglin Zhang,

Xiaojing Yin

et al.

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2024

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Cited by 4 publications

References 69 publications

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Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

Yin,

Lai,

Zhang

et al. 2024

Advanced Science

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Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan‐conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug‐resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies.

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Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

Yin,

Lai,

Zhang

et al. 2024

Advanced Science

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A Natural Eumelanin‐Assisted Pullulan/Chitosan Hydrogel for the Management of Diabetic Oral Ulcers

Li,

Xiang,

Chen

et al. 2024

Macromolecular Bioscience

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Existing methods for treating diabetic oral ulcers often fall short in clinical environments due to potential bacterial contamination, oxidative harm, and hindered angiogenesis throughout the healing process. Here, a hydrogel patch (HYG2) have been developed for local in situ application. HYG2 comprises oxidized pullulan, quaternized chitosan, and eumelanin nanoparticles derived from cuttlefish ink. These components work together to efficiently heal wounds associated with diabetic oral ulcers. Application begins with a simple local injection that quickly forms a protective barrier over the mucosa, effectively stopping bleeding and counteracting inflammatory agents. HYG2 is distinguished by its strong antibacterial properties and capacity to eliminate reactive oxygen species, promoting bacteria clearance and managing oxidative stress, which accelerates the healing phase from inflammation to tissue regeneration. Additionally, HYG2's 3D structure, incorporating elements from natural sources, offers exemplary support for structural and nutritional cell needs. This enhancement fosters cell adhesion, migration, and proliferation, along with further angiogenesis during mucosal remodeling. Ultimately, HYG2 is fully absorbed by the body after serving its therapeutic functions. Evidence from in vitro and in vivo studies shows that HYG2 hydrogel markedly accelerates mucosal wound repair, making it a promising treatment for diabetic oral ulcers.

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Exploring the therapeutic potential of yeast β-glucan: Prebiotic, anti-infective, and anticancer properties - A review

Xu,

Wu,

Luo

et al. 2024

International Journal of Biological Macromolecules

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An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota

Cited by 4 publications

References 69 publications

Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

A Natural Eumelanin‐Assisted Pullulan/Chitosan Hydrogel for the Management of Diabetic Oral Ulcers

Exploring the therapeutic potential of yeast β-glucan: Prebiotic, anti-infective, and anticancer properties - A review

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