An anticancer-active imidazole analogue as a fluorescent sensor: sensitive and selective detection of Cu2+ ions

Recent Advances in the Development of Near-Infrared Fluorescent Probes for the in Vivo Brain Imaging of Amyloid-β Species in Alzheimer’s Disease

“…The presence of nitrogen donor atoms in the structure of the imidazole core provides ligating ability to its derivatives with the metal ions. 52 In 2013, Zhang et al reported CRANAD-17, imidazole-containing curcumin analogs for in vivo fluorescence imaging and selectively interrupting the copper-induced crosslinking. Imidazoles from H13 and H14 of Aβ served as essential binding sites for metal coordination.…”

“…In the past, imidazole derivatives have been reported to have chemosensor properties that lie in the significant change of fluorescence and absorbance upon metal binding. The presence of nitrogen donor atoms in the structure of the imidazole core provides ligating ability to its derivatives with the metal ions . In 2013, Zhang et al reported CRANAD-17 , imidazole-containing curcumin analogs for in vivo fluorescence imaging and selectively interrupting the copper-induced cross-linking.…”

New Oxoquinoline‐Imidazole Based Fluorescence Signaling Switches for the Determination of Zn2+/F− (OFF‐ON), and Fe3+/Picric Acid (ON‐OFF): Applications in Anticancer Activity

“…ESIPT-based sensors received huge attention in designing the fluorescent probes due to their huge Stokes shift, minimized self-absorption, and elimination of the interference from self-fluorescence for bioimaging. [44,45] Notably, several imidazole-based derivatives have been reported due to their potential application in biological systems [46][47][48] and also as sensors in the determination of anions [49][50][51] and the fabrication of light-emitting diodes. [52][53][54][55][56] In particular, 2-hydroxy substituted tetraphenyl imidazole was employed extensively due to applications in solar energy, concentrators, chemosensors, electroluminescent materials, and laser dyes.…”