An anticancer/cytotoxic activity of resveratrol is not hampered by its ability to induce the expression of the antioxidant/cytoprotective heme oxygenase-1 in RAW264.7 cells

Kil, Jin Sang; Son, Young‐Ik; Cheong, Yong‐Kwan; Kim, Nam-Ho; Jeong, Hee Jong; Kang, Sung Goo; Chung, Hun‐Taeg; Pae, Hyun‐Ock

doi:10.1016/j.bionut.2011.02.006

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In a study by Kil et al [28], it was confirmed that, at a concentration of 80 µM, resveratrol had a cytotoxic effect on the cells of murine macrophages (RAW264.7) by producing large amounts of free radicals. Moreover, in the studies by Zhang et al [29], it was found that resveratrol and its synthetic derivatives can act against cancer by initiating the lipid peroxidation process in colon cancer cells, thus leading to the phenomenon of ferroptosis.…”

Section: Discussionmentioning

confidence: 91%

The Effect of Resveratrol and Static Magnetic Field Interactions on the Oxidation–Reduction Parameters of Melanoma Malignant Cells

2023

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Background: Scientific research has confirmed the biological activity of resveratrol, which includes its antioxidant, anti-inflammatory, cardioprotective and anticancer properties. There is no known interaction between a static magnetic field and resveratrol that can modulate resveratrol’s effect on cells. Thus, the main aim of our research was to assess the effect of the co-exposure to resveratrol and a static magnetic field on the oxidation–reduction homeostasis of C32 and Colo829 melanoma cells. Methods: The studies consisted of determining the activity of the antioxidant enzymes that constitute the body’s first line of defense—SOD, GPx and CAT—and determining the lipid peroxidation product—MDA—and the value of the total antioxidant status of melanoma cells. Results and conclusions: Resveratrol was shown to exhibit anticancer properties, possibly through the ferroptosis of melanoma cells. A static magnetic field was also found to abolish the anticancer properties of resveratrol and to have a protective effect against melanoma cells by restoring the redox balance in the cells.

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Section: Discussionmentioning

confidence: 91%

The Effect of Resveratrol and Static Magnetic Field Interactions on the Oxidation–Reduction Parameters of Melanoma Malignant Cells

2023

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“…The cytotoxic effect of RV was evaluated in C6 cells after incubation for 24 h and 72 h. The cell viability was decreased with the increasing concentrations of RV and the IC50 values of RV were found to be 85 and 15 μM respectively in this cell line (18). It was observed that RV reduced cell viabilityapproximately 35% measured by MTT assay in RAW264.7 cells after 24 h treatment (19). In an another study, it is claimed that RV enhanced the anti-cancer effect induced by As 2 O 3 in vitro (31).…”

Section: Discussionmentioning

confidence: 93%

“…Data showed that RV has antioxidant, anti-inflamatory, anti-cancer activities (13)(14)(15). It has been shown that RV has cytotoxic potential in human breast adenocarcinoma (MCF-7), rat brain glioma (C6), human neuroblastoma (SH-SY5Y), African green monkey kidney fibroblast (CV1-P), mouse macrophage (RAW264.7), mouse fibroblast (3T6) and the human promyelocytic leukemia tumor (HL60) cells (16)(17)(18)(19). But studies about RV"s ctotoxicity using HeLa, V79 and MDA-MB 231 cell lines is limited and also there are some studies reporting that RV has not cytotoxic effects aganist cancer cells.Molecules which can inhibit cell growth in tumor cells, without significantly affecting the viability of normal cells, represent potential anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxıc Actıvıty of Resveratrol in Dıfferent Cell Lınes Evaluated by MTT and NRU Assays

Göktaş¹,

Bacanlı²,

Kutluk³

et al. 2016

Turk J Pharm Sci

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Oxidative stress is the state of imbalance between the level of antioxidant defence system and production of reactive oxygen species (ROS) and is involded in the progression of several diseases such as inflammation, cancer, neurodegenerative disorders and cardiovascular diseases. It is suggested that plant polyphenols may act as antioxidants and therefore it has anticancer activities. Resveratrol (RV), is a naturally occuring polyphenolic compound which is found in many plant species including grapes, nuts, blueberries and raspberries. Data indicated that it has anti-oxidant, anti-inflamatory and anti-cancer activities. But there are also some studies reported that RV has not protective effects aganist cancer. In this study, the cytotoxicity of RV in human breast adenocarcinoma (MDA-MB 231), human cervical cancer (HeLa) and Chinese hamster lung fibroblast(V79) cells were evaluated by Neutral Red uptake assay (NRU) and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays after incubation at 24 h. We obtained more or the less same results by two cytotoxicity assays. In the concentrations between 2-400 µM, RV seemed not to induce a pronounced cytotoxicity in all cell types. Even at highest concentrations, it showed almost no cytotoxic effects. So the IC50 values were not calculated at the studied concentrations.

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The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity

Xie

Liu

Shi

et al. 2021

Bioorganic & Medicinal Chemistry Letters

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An anticancer/cytotoxic activity of resveratrol is not hampered by its ability to induce the expression of the antioxidant/cytoprotective heme oxygenase-1 in RAW264.7 cells

Cited by 4 publications

References 20 publications

The Effect of Resveratrol and Static Magnetic Field Interactions on the Oxidation–Reduction Parameters of Melanoma Malignant Cells

The Effect of Resveratrol and Static Magnetic Field Interactions on the Oxidation–Reduction Parameters of Melanoma Malignant Cells

Cytotoxıc Actıvıty of Resveratrol in Dıfferent Cell Lınes Evaluated by MTT and NRU Assays

The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity

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