An anticancer drug sensitivity test to determine the effectiveness of UFT as postoperative adjuvant chemotherapy for patients with stage III colorectal cancer

Isogai, Akiko; Nagaya, Masaki; Matsuoka, Hiromitsu; Watanabe, Taiji; Tsukikawa, Satoshi; Kubota, Sunao

doi:10.1016/j.surg.2007.06.017

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…However, further studies are required in order to improve the comprehending of their biological behaviors and to draft the optimum therapeutic approach. Nowadays, the experiment of anticancer drug sensitivity in vitro is the evidence in the chemotherapy and has become a highlight for the realization of individual tumor treatment [ 28 , 29 ]. In our case, the tumor relapsed via microlaryngoscopic surgery combined with initial chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Lü

Ren

et al. 2020

BMC Surg

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Background Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. Case presentation A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. Conclusions Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor.

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Section: Discussionmentioning

confidence: 99%

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Lü

Ren

et al. 2020

BMC Surg

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“…Therefore, we aim to develop a new method that predicts the therapeutic effect of adjuvant chemotherapy and enables decision-making regarding whether patients should be administered 5-FU-based or l-OHP-based chemotherapy. Several molecular markers have been considered as satisfactory predictors of the efficacy of 5-FU-based chemotherapy (4–6), although studies on the effectiveness of in vitro drug sensitivity tests are limited (19). …”

Section: Discussionmentioning

confidence: 99%

Clinical predictive value of in vitro anticancer drug sensitivity test for the therapeutic effect of adjuvant chemotherapy in patients with stage II–III colorectal cancer

Mekata

Sonoda

Shimizu

et al. 2013

Molecular and Clinical Oncology

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Clinically useful predictors of the efficacy of adjuvant chemotherapy following curative colorectal surgery remain to be determined. In the present study, we investigated the clinical utility of the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) as a predictor of the therapeutic response to 5-fluorouracil (5-FU)-based adjuvant chemo-therapy in patients with stage II–III colorectal cancer. CD-DST was conducted using tumor samples surgically obtained from 189 patients. The therapeutic effect of 5-FU-based regimens between high (high-group) and low (low-group) sensitivity groups and a group that did not receive chemotherapy [CTx(-) group] was compared. CD-DST was successfully performed in 151 out of the 189 patients (79.9%), 87 of whom received 5-FU-based adjuvant chemotherapy after surgery. Twenty-seven of these 87 patients (31.0%) were classified as the high-group and the remaining 60 (69.0%) as the low-group. The 5-year recurrence-free survival (RFS) in the high-group was significantly higher compared to that in the low- and the CTx(-) groups. No differences in the 5-year RFS were observed between the low- and CTx(-) groups. In conclusion, CD-DST appears to be useful for predicting the therapeutic response to 5-FU-based adjuvant chemotherapy in patients with stage II-III colorectal cancer.

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“…In particular, stage III CRC patients who undergo curative surgery can benefit from anti-cancer drugs, including those administered orally [28,29]. …”

Section: Discussionmentioning

confidence: 99%

Insufficient Lymph Node Dissection Is an Independent Risk Factor for Postoperative Cancer Death in Patients Undergoing Surgery for Stage II Colorectal Cancer

Ishizuka¹,

Nagata²,

Takagi³

et al. 2010

Eur Surg Res

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Background: Surgical resection is the most effective treatment for patients with stage II colorectal cancer (CRC). However, a few patients with early-phase CRC suffer postoperative cancer death. Aims: To investigate the risk factors for postoperative cancer death in patients who undergo surgery for stage II CRC. Methods: Prognostic significance was analyzed by χ² test, univariate analyses, Kaplan-Meier analysis and log-rank test using clinicopathological factors from the database. Results: A total of 205 patients with stage II CRC were evaluated. Age (≤65/>65 years), venous invasion (negative/positive), number of dissected lymph nodes (≤9/≧10), grade of lymph node dissection (sufficient/insufficient) and albumin level (<3.5/≧3.5 g/dl) were associated with shorter overall survival. Univariate analysis of the clinicopathological factors revealed that only the grade of lymph node dissection (sufficient/insufficient) was associated with postoperative cancer death (odds ratio 2.993, 95% confidence interval 1.216–7.368, p = 0.017).Kaplan-Meier analysis and log-rank test revealed that the group with insufficient lymph node dissection had a higher incidence of postoperative cancer death than the group with sufficient dissection (p < 0.001). Conclusions: Insufficient lymph node dissection is an independent risk factor for postoperative cancer death in patients who undergo surgery for stage II CRC.

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An anticancer drug sensitivity test to determine the effectiveness of UFT as postoperative adjuvant chemotherapy for patients with stage III colorectal cancer

Cited by 5 publications

References 22 publications

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Clinical predictive value of in vitro anticancer drug sensitivity test for the therapeutic effect of adjuvant chemotherapy in patients with stage II–III colorectal cancer

Insufficient Lymph Node Dissection Is an Independent Risk Factor for Postoperative Cancer Death in Patients Undergoing Surgery for Stage II Colorectal Cancer

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