An antifungal coating for dental silicones composed of chlorhexidine nanoparticles

Garner, Sarah J.; Nobbs, Angela H.; McNally, Lisa; Barbour, Michele E

doi:10.1016/j.jdent.2014.12.005

Cited by 34 publications

(31 citation statements)

References 35 publications

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“…Only a few works in the past years were focused on the possibilities of developing silicone soft lining materials with enhanced antifungal activity. Garner et al [ 36 ] investigated antifungal coating composed of chlorhexidine nanoparticles on silicone rubber and showed inhibited metabolic activity of C. albicans , which is a very good prognostic before further investigations. This interesting method may allow in the future to renew the active layer when antimicrobial properties expire.…”

Section: Discussionmentioning

confidence: 99%

“…Different strategies have been used experimentally to increase the antifungal resistance of acrylic [ 34 ] and silicone [ 35 , 36 , 37 ] long-term soft denture lining materials with varying degrees of success. In this study, we report the use of silver sodium hydrogen zirconium phosphate (SSHZP) as a submicron filler for silicone matrix used as denture soft liners.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Silver-Emitting Filler on Antimicrobial and Mechanical Properties of Soft Denture Lining Material

et al. 2018

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Colonization of silicone-based soft lining materials by pathogenic yeast-type fungi is a common problem associated with the use of dentures. In this study, silver sodium hydrogen zirconium phosphate (SSHZP) was introduced into polydimethylsiloxane-based material as an antimicrobial filler at concentrations of 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12, and 14% (w/w). The in vitro antimicrobial efficacy was investigated. Candida albicans was used as a characteristic representative of pathogenic oral microflora. Staphylococcus aureus and Escherichia coli were used as the typical Gram-positive and Gram-negative bacterial strains, respectively. The effect of filler addition on the Shore A hardness, tensile strength, tensile bond strength, sorption, and solubility was investigated. An increase in the filler concentration resulted in an increase in hardness, sorption, and solubility, and for the highest concentration, a decrease in bond strength. The favorable combination of antimicrobial efficacy with other properties was achieved at filler concentrations ranging from 2% to 10%. These composites exhibited mechanical properties similar to the material without the antimicrobial filler and enhanced in vitro antimicrobial efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Silver-Emitting Filler on Antimicrobial and Mechanical Properties of Soft Denture Lining Material

et al. 2018

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“…Platinum nanoparticles (PtNPs) are considered antioxidants because of their strong catalytic activity and preventative effect on oxidative stress-associated pathologies (Yoshihisa et al 2011). Recently, many studies have shown the beneficial application of nanoparticles in dentistry, where NPs demonstrated antimicrobial effects (Garner et al 2015), improved bonding to methacrylate-based materials (Oliveira-Ogliari et al 2015), or improved mechanical properties of resin composites (Sokołowski et al 2014). Other studies reported that silver NPs used in dentin primers improved their antibacterial effects or antibiofilm efficacy around resin restorations or cements (Zhang et al 2013;Imazato et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity

et al. 2015

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Nanoparticles (NPs) are currently the focus of considerable attention for dental applications; however, their biological effects have not been fully elucidated. The long-term, slow release of matrix metalloproteases (MMPs) digests collagen fibrils within resin-dentin bonds. Therefore, MMP inhibitors can prolong the durability of resin-dentin bonds. However, there have been few reports evaluating the combined effect of MMP inhibition and the cytotoxic effects of NPs for dentin bonding. The aim of this study was to evaluate MMP inhibition and cytotoxic responses to gold (AuNPs) and platinum nanoparticles (PtNPs) stabilized by polyvinylpyrrolidone (PVP) in cultured murine macrophages (RAW264) by using MMP inhibition assays, measuring cell viability and inflammatory responses (quantitative reverse transcription polymerase chain reaction [RT-qPCR]), and conducting a micromorphological analysis by fluorescence and transmission electron microscopy. Cultured RAW264 cells were exposed to metal NPs at various concentrations (1, 10, 100, and 400 µg/mL). AuNPs and PtNPs markedly inhibited MMP-8 and MMP-9 activity. Although PtNPs were cytotoxic at high concentrations (100 and 400 µg/mL), no cytotoxic effects were observed for AuNPs at any concentration. Transmission electron microscopy images showed a significant nonrandom intercellular distribution for AuNPs and PtNPs, which were mostly observed to be localized in lysosomes but not in the nucleus. RT-qPCR analysis demonstrated inflammatory responses were not induced in RAW264 cells by AuNPs or PtNPs. The cytotoxicity of nanoparticles might depend on the core metal composition and arise from a "Trojan horse" effect; thus, MMP inhibition could be attributed to the surface charge of PVP, which forms the outer coating of NPs. The negative charge of the surface coating of PVP binds to Zn(2+) from the active center of MMPs by chelate binding and results in MMP inhibition. In summary, AuNPs are attractive NPs that effectively inhibit MMP activity without cytotoxicity or inflammatory responses.

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“…24 Ultimately the decision to choose between using a soft lining materials or hard acrylic resin lies with the clinician based upon an individual patient's needs and replacement of this bung at regular intervals should be carefully considered in the design of the prosthesis.…”

Section: Discussionmentioning

confidence: 99%