2009
DOI: 10.1002/cbdv.200800336
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An Antifungal Tetrapeptide from the Culture of Penicillium canescens

Abstract: A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D-NMR, and MS and MS/MS) and… Show more

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Cited by 39 publications
(29 citation statements)
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“…Kjer et al (2009) isolated Alternaria sp. with antimicrobial activity from the mangrove plant, also Bertinetti et al (2009) recorded endophytic Penicillium sp. as antifungal metabolite producer.…”
Section: Discussionmentioning
confidence: 96%
“…Kjer et al (2009) isolated Alternaria sp. with antimicrobial activity from the mangrove plant, also Bertinetti et al (2009) recorded endophytic Penicillium sp. as antifungal metabolite producer.…”
Section: Discussionmentioning
confidence: 96%
“…Compounds found in the uninoculated PDA medium (control) are not included in this table and were used to subtract any possible compounds from the medium. Different superscript lower case letters denote statistically significant differences (p < 0.05) between fungal species 2013) and P. canescens (Bertinetti et al 2009;Nicoletti et al 2014) was only explored against phytopathogenic fungi. Studies focusing antimicrobial activity of P. commune against human pathogens are mainly performed with marine sediment-derived strains (Gao et al 2011).…”
Section: Discussionmentioning
confidence: 99%
“…All identified taxon in this study, Alternaria (Kjer et al, 2009), Phomopsis (Du et al, 2008, Penicillium (Bertinetti et al, 2009), Pestalotiopsis (Liu, 2011, basidiomycete (Suay et al, 2000) and Streptomyces (Maruna et al, 2010) had already been described as producers of metabolite with antimicrobial activity. Although the TLC method is only qualitative, it is a simple and relatively cheap technique to recognize the inhibitory activity of a large quantity of organic extracts.…”
Section: Discussionmentioning
confidence: 59%