An antigen in normal avian cells which confuses virological and serological tests

SUMMARYThe occurrence of anti-nuclear antibodies in fowl sera is described. The anti-nuclear activity was demonstrated by immunofluorescence in a small percentage (3.9%) of the sera tested. The nuclei of cultured fowl and turkey cells were stained by anti-nuclear serum whereas the nuclei of several mammalian tissues were not.Staining of chicken kidney cell nuclei by anti-nuclear serum conjugated with fluorescein isothiocyanate was blocked by unconjugated anti-nuclear serum but not by serum without anti-nuclear activity indicating the specificity of the reaction. The possible confusion between anti-nuclear staining and specific viral staining is discussed, along with the possible association of anti-nuclear factors with disease in birds.

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An antigen in normal avian cells which confuses virological and serological tests

Cited by 2 publications

References 21 publications

Standardization of reagents for serological tests to detect infections in poultry

Standardization of reagents for serological tests to detect infections in poultry

Demonstration of anti‐nuclear antibodies in fowl sera by immunofluorescence

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