An antihistaminic agent: soventol hydrochloride monohydrate ethanol solvate

Abstract

Introduction. Intensity data from a single crystal, 0.35 × 0.35 × 0.20 mm, were recorded at room temperature on a Nonius CAD-4 computer-controlled diffractometer with graphite-monochromatized Mo radiation and the 09--20 scan mode. Measurements of 3458 independent reflexions, including 969 with negative intensities, were made with 0 < 24 °. All reflexions were included in the structure refinement, the unobserved (mentioned above) were given I = 0 and appeared in the refinement with AF = -F c. Two standard reflexions were measured regularly throughout the data collection and the intensity of both dropped by 22%. 15% of this decay was in the first half of data collection when the surface of the crystal became opaque. Once the crystal became coated, the intensities decayed at a much slower rate. Lp corrections were applied, but an absorption correction was ignored.

Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

“…As shown in Figure , pharmaceuticals prepared via reductive aminations include the following: (a) Buclizine, an antihistamine and antiemetic; (b) Meclizine, used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness; (c) Flunarizine, a selective calcium entry blocker; (d) Cinacalcet, a calcium sensing receptor agonist; (e) Piribedil, used in the treatment of Parkinson’s disease; and (f) Donepezil, used to treat the behavioral and cognitive effects of Alzheimer’s Disease and other types of dementia . The preparation of intermediate 29 serves as the precursor to both Bamipine, an antipruritic ointment, and Antazoline, an antihistamine . Product 30 functions as a precursor to Fipexide, used as a nootropic drug mainly for the treatment of senile dementia .…”