An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Ghanim, Husam; Sia, Chang Ling; Abuaysheh, Sanaa; Korzeniewski, Kelly; Patnaik, Priyanka; Marumganti, Anuritha; Chaudhuri, Ajay; Dandona, Paresh

doi:10.1210/mend.24.7.9998

Cited by 47 publications

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“…Reduction in ROS and tumor necrosis factor-a as well as inflammation markers interleukin-6 and C-reactive protein is achieved in participants who received resveratrol [134]. Serious side-effects are not observed [133][134][135][136] in the known human experiments. In phase I dose escalation pharmacokinetic study in healthy volunteers, the increase in blood bilirubin and alanine aminotransferase is observed, which are potentially related to resveratrol administration [135].…”

Section: Discussionmentioning

confidence: 88%

“…In one phase I study, resveratrol intake for 4 weeks by healthy volunteers caused a small but significant decrease in circulating IGF-1 and IGF-binding protein 3 compared with pre-dosing values [133]. Reduction in ROS and tumor necrosis factor-a as well as inflammation markers interleukin-6 and C-reactive protein is achieved in participants who received resveratrol [134]. Serious side-effects are not observed [133][134][135][136] in the known human experiments.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol in cardiovascular disease: what is known from current research?

et al. 2011

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Resveratrol is a well-known antioxidant that exists in grape skin/seed, red wine, and the root of Polygonum cuspidatum, a traditional Chinese and Japanese medicinal material. Studies have found that resveratrol has many interesting properties, including anti-carcinogenic properties, anti-microbial and antiviral effects, the ability to reverse dyslipidemia and obesity, the ability to attenuate hyperglycemia and hyperinsulinemia, and the ability to protect endothelial function. Heart failure is the final consequence of the majority of cardiovascular diseases, and resveratrol has been shown to directly attenuate heart contraction. The cardiovascular protective capacities of resveratrol are associated with multiple molecular targets and may lead to the development of novel therapeutic strategies for atherosclerosis, ischemia/reperfusion, metabolic syndrome, and heart failure. This article will mainly review recently published basic researches about the protective cardiovascular effects of resveratrol because these results may lead to the development of new clinical therapeutics in patients.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Resveratrol in cardiovascular disease: what is known from current research?

et al. 2011

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“…Similarly, a trial of 40 patients after a myocardial infarction treated with 10 mg resveratrol for 3 months found some improvement in flow-mediated dilation and a decrease in LDL levels [204]. Two small trials exploring the effects of resveratrol on metabolic parameters found that resveratrol improved post-meal glucose levels in patients with impaired glucose tolerance, and reduced markers of oxidative stress in healthy subjects [205,206]. The most recent small clinical trial reported that resveratrol had no positive effects on non-alcoholic fatty liver disease subjects given 3 g resveratrol daily for 8 weeks [207].…”

Section: Resveratrol In Humansmentioning

confidence: 99%

Metabolic effects of resveratrol: addressing the controversies

Bitterman

Chung

2014

Cell. Mol. Life Sci.

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Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol.

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“…This finding was confirmed by the decreased expression of p47phox, NFjB, JNK-1, PTP-1B and SOCS-3 in peripheral blood mononuclear cells (PBMC) [11]. Furthermore, resveratrol inhibited the expression of TNF-a, IL-6 and C-reactive protein [11]. Other studies showed that resveratrol had antimicrobial activities against both bacterial strains, such as Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa, and fungal strains, such as Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton rubrum, Epidermophyton floccosum, and Microsporum gypseum [5].…”

Section: Introductionmentioning

confidence: 73%

“…Resveratrol also showed protective effects against oxidative stress and inflammation by substantially reducing reactive oxygen species (ROS) generation. This finding was confirmed by the decreased expression of p47phox, NFjB, JNK-1, PTP-1B and SOCS-3 in peripheral blood mononuclear cells (PBMC) [11]. Furthermore, resveratrol inhibited the expression of TNF-a, IL-6 and C-reactive protein [11].…”

Section: Introductionmentioning

confidence: 82%

Novel Antifungal Mechanism of Resveratrol: Apoptosis Inducer in Candida albicans

Lee

2014

Curr Microbiol

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Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a well-known natural polyphenolic compound that has garnered considerable interest because of its bioavailability and pharmacokinetics in humans. Although the antimicrobial activity of resveratrol has recently been focused, however, the antifungal activity and its mechanism are still largely unknown. Here, we report for the first time the potential of resveratrol as an apoptosis inducer in the human pathogenic fungus Candida albicans. The results showed that resveratrol exerted its effects from the early to the late stages of apoptosis and involved the activity of reactive oxygen species, particularly hydroxyl radicals ((∙)OH). DiOC6(3) and JC-1 staining indicated that loss of mitochondrial membrane potential (ΔΨ m) is a key event in resveratrol-induced apoptosis. Finally, we investigated metacaspase activation resulting from mitochondrial dysfunction. The result showed that resveratrol strongly activated metacaspase and promoted cytochrome c release. In summary, resveratrol induces fungal apoptosis through a caspase-dependent mitochondrial pathway and is a potential agent for treating human fungal diseases.

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An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol

Cited by 47 publications

References 0 publications

Resveratrol in cardiovascular disease: what is known from current research?

Resveratrol in cardiovascular disease: what is known from current research?

Metabolic effects of resveratrol: addressing the controversies

Novel Antifungal Mechanism of Resveratrol: Apoptosis Inducer in Candida albicans

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