An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases

Sani, Ehsan Shirzaei; Portillo-Lara, Roberto; Aldawood, Zahra; Bassir, Seyed Hossein; Nguyen, Daniel H.; Kantarcı, Alpdoğan; Intini, Giuseppe; Annabi, Nasim

doi:10.1016/j.matt.2019.07.019

Cited by 106 publications

(76 citation statements)

References 62 publications

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“…The material was biocomtible and has antimicrobial activity against Clostridium sporogenes 93 . An antimicrobial dental light curable bioadhesive hydrogel composed of visible-light-activated naturally derived polymer (gelatin) and an antimicrobial peptide developed by sani et al has higher adhesion to physiological tissues and showed antimicrobial actvity against P. gingivalis 94 . Chen et al developed an thermosensitive nanoparticle hydrogel for the delivery of ibuprofen and basic fibroblast growth factor.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Johnson

Kong

Miao

et al. 2020

Sci Rep

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Periodontitis is an inflammatory disease that can lead to the periodontal pocket formation and tooth loss. This study was aimed to develop antimicrobials loaded hydrogels composed of cellulose nanofibers (CNF) and κ-carrageenan oligosaccharides (CO) nanoparticles for the treatment of periodontitis. Two antimicrobial agents such as surfactin and Herbmedotcin were selected as the therapeutic agents and the hydrogels were formulated based on the increasing concentration of surfactin. The proposed material has high thermal stability, controlled release, and water absorption capacity. This study was proceeded by investigating the in vitro antibacterial and anti-inflammatory properties of the hydrogels. This material has strong antibacterial activity against periodontal pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, and Pseudomonas aeruginosa. Moreover, a significant increase in malondialdehyde (MDA) production and a decrease in biofilm formation and metabolic activity of the bacteria was observed in the presence of hydrogel. Besides, it reduced the reactive oxygen species (ROS) generation, transcription factor, and cytokines production in human gingival fibroblast cells (HGF) under inflammatory conditions. In conclusion, the hydrogels were successfully developed and proven to have antibacterial and anti-inflammatory properties for the treatment of periodontitis. Thus, it can be used as an excellent candidate for periodontitis treatment.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Johnson

Kong

Miao

et al. 2020

Sci Rep

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“…In a follow-up study, Annabi et al used a combination of GelMA and MeTro encapsulated with Tet213 to create a sprayable and antimicrobial tissue adhesive [59]. The adhesive was crosslinked using an Eosin-Y based photoinitiating system as described elsewhere [46]. The negligible inflammatory response after the subcutaneous implantation of the adhesive in rats showed the biocompatibility of the hydrogel created from the combination of MeTro and GelMA.…”

Section: Recombinant Protein-derived Photoreactive Tissue Adhesivesmentioning

confidence: 99%

“…GelMA sealant did not elicit an inflammatory host response and degraded with time after adequate wound healing. To avoid the usage of a UV light source that may cause tissue damage, Sani et al created GelMA sealants that can be crosslinked using an alternative photochemistry [46]. A combination of Eosin-Y (Norrish type II, λ rxn~5 14 nm), triethanolamine (TEA, coinitiator), and N-vinylcaprolactam (coinitiator) was used as the visible light photoinitiator system for crosslinking GelMA, and an antimicrobial peptide (Tet213) was added to the mixture to reduce the risk of infections at the place of injury.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial GelMa adhesive showed stronger adhesion to porcine gingiva compared to commercially available Coseal TM . Additionally, the GelMA sealant showed potential applications in treating perimplanting disease in rat calvarial defects ( Figure 2) [46]. triethanolamine (TEA, coinitiator), and N-vinylcaprolactam (coinitiator) was used as the visible light photoinitiator system for crosslinking GelMA, and an antimicrobial peptide (Tet213) was added to the mixture to reduce the risk of infections at the place of injury.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

Narayanan

Dhinojwala

et al. 2020

ChemEngineering

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To stop blood loss and accelerate wound healing, conventional wound closure techniques such as sutures and staples are currently used in the clinic. These tissue-piercing wound closure techniques have several disadvantages such as the potential for causing inflammation, infections, and scar formation. Surgical sealants and tissue adhesives can address some of the disadvantages of current sutures and staples. An ideal tissue adhesive will demonstrate strong interfacial adhesion and cohesive strength to wet tissue surfaces. Most reported studies rely on the liquid-to-solid transition of organic molecules by taking advantage of polymerization and crosslinking reactions for improving the cohesive strength of the adhesives. Crosslinking reactions triggered using light are commonly used for increasing tissue adhesive strength since the reactions can be controlled spatially and temporally, providing the on-demand curing of the adhesives with minimum misplacements. In this review, we describe the recent advances in the field of naturally derived tissue adhesives and sealants in which the adhesive and cohesive strengths are modulated using photochemical reactions.

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Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Yin

Yang

et al. 2023

Adv Funct Materials

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Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy.

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An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases

Cited by 106 publications

References 62 publications

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

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