An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

Abstract

Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

“…Mitochondrial damage and inflammation often share an inseparable relationship, with the change of mitochondria-mediated by mtROS and Ca 2+ dysfunction serving as a crucial nexus in this interaction. Persistent and unregulated inflammation is always found in numerous human diseases with obvious mitochondrial damage, which is not limited to autoimmune disease [108] but also includes neurological, [109] cardiovascular, [110] renal, and hepatic disease. [111,112] The inflammation will as a bona fide disease driver or an accomplice in disease deterioration.…”

“…Wang et al constructed PD microenvironment-driven engineered exosomes with multistep targeting and multistage intervention method. Zwitterionic poly(methacrylate arginine) Cardiac repair SOD-ZrMOF [ 110] --154 -SOD Cardiomitochondrial protection PDA-NPs [ 244] --≈180 ≈-25 Polydopamine…”

Nanomedicine‐Based Therapeutics for Myocardial Ischemic/Reperfusion Injury

“…synthesized a metal‐organic framework (MOF) to immobilize SOD (SOD‐ZrMOF) for cardiac injury repair. [ 83 ] SOD‐ZrMOF was highly biocompatible. In ischemic cardiac tissues, the SOD‐ZrMOF (1 µg/per mouse, intramyocardial injection once) remarkably detoxifies O 2 • − , improves cardiac function, and reduces the infarction area.…”

Platelet Membrane‐Encapsulated Nanocomplexes Based on Profundity Scavenging ROS Strategy for Myocardial Infarction Therapy

“…[8] Tang et al developed a kind of immobilized enzyme with superoxide dismutase (SOD) activity and Zr-based metal-organic framework (ZrMOF) cross-linking (SOD-ZrMOF) to reduce the damage caused by ROS for myocardial repair treatment. [9] Que et al developed a Zn 2 SiO 4 bioceramic with a synergistic effect on promoting endothelial cell angiogenesis, inhibiting myocardial cell apoptosis, and protecting myocardial mitochondria. [10] Within the realm of antioxidant therapeutic strategies, our research group has extensively investigated melanin, focusing our studies on its remarkable antioxidant effects.…”

“…developed a kind of immobilized enzyme with superoxide dismutase (SOD) activity and Zr‐based metal‐organic framework (ZrMOF) cross‐linking (SOD‐ZrMOF) to reduce the damage caused by ROS for myocardial repair treatment. [ 9 ] Que et al. developed a Zn 2 SiO 4 bioceramic with a synergistic effect on promoting endothelial cell angiogenesis, inhibiting myocardial cell apoptosis, and protecting myocardial mitochondria.…”