An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment

Chen, Jiachen; Wu, Jiahe; Mu, Jiafu; Li, Liming; Hu, Jingyi; Lin, Hangjuan; Cao, Jian

doi:10.1016/j.nano.2022.102625

Cited by 12 publications

(8 citation statements)

References 45 publications

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“…Additionally, the sustained and controlled release of these agents from hydrogels further enhances the potential effectiveness of treatment. Relevant scholarly sources [ 85 , 106 , 120 , 131 , 149 , 159 , 160 ] have also supported this notion. Consequently, the utilization of EVs holds immense promise for the development of therapeutic interventions aimed at improving outcomes for individuals with SCI [ 85 ].…”

Section: Discussionmentioning

confidence: 84%

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Zhiguo,

Ji,

Shenyuan

et al. 2023

J Nanobiotechnol

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Extracellular vesicles (EVs) in the field of spinal cord injury (SCI) have garnered significant attention for their potential applications in diagnosis and therapy. However, no bibliometric assessment has been conducted to evaluate the scientific progress in this area. A search of articles in Web of Science (WoS) from January 1, 1991, to May 1, 2023, yielded 359 papers that were analyzed using various online analysis tools. These articles have been cited 10,842 times with 30.2 times per paper. The number of publications experienced explosive growth starting in 2015. China and the United States led this research initiative. Keywords were divided into 3 clusters, including “Pathophysiology of SCI”, “Bioactive components of EVs”, and “Therapeutic effects of EVs in SCI”. By integrating the average appearing year (AAY) of keywords in VoSviewer with the time zone map of the Citation Explosion in CiteSpace, the focal point of research has undergone a transformative shift. The emphasis has moved away from pathophysiological factors such as “axon”, “vesicle”, and “glial cell” to more mechanistic and applied domains such as “activation”, “pathways”, “hydrogels” and “therapy”. In conclusions, institutions are expected to allocate more resources towards EVs-loaded hydrogel therapy and the utilization of innovative materials for injury mitigation.

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Section: Discussionmentioning

confidence: 84%

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Zhiguo,

Ji,

Shenyuan

et al. 2023

J Nanobiotechnol

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“…The sustained release, cellular uptake, and longterm maintenance observed effectively improved the microenvironment and nerve recovery. 168 Gelatin methacryloyl-based hydrogels (GelMA and ColMA) that mimic native ECM in many respects have favorable biological properties and exhibit…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

“…The sustained release, cellular uptake, and long-term maintenance observed effectively improved the microenvironment and nerve recovery. 168 Gelatin methacryloyl-based hydrogels (GelMA and ColMA) that mimic native ECM in many respects have favorable biological properties and exhibit tunable physical properties in a wide variety of applications that enable neural tissue engineering. 169 GelMA and ColMA, photo-crosslinkable-based biomaterials, are currently used in various biomedical applications such as tissue regeneration, drug delivery, and tissue adhesion due to their favorable biological properties in the class of injectable polymers.…”

Section: Hydrogel Incorporation With Exo For Extracellular Matrix Mod...mentioning

confidence: 99%

Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Zakeri,

Heiderzadeh,

Kocaarslan

et al. 2024

Biomater. Sci.

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“…These innovative materials exhibit favorable properties that could pave the way for developing novel therapies for SCIs. Excessive ROS exacerbates SCI, and Chen et al [56] produced a specific polydopamine-modified hydrogel, which modulated the inflammatory and oxidative conditions of the spinal cord by regulating the oxidative stress microenvironment and reducing ROS. Proinflammatory M1 macrophages at the lesions exacerbate the degree of injury at the secondary injury stage.…”

Section: The Related Therapeutic Mechanism Of Hydrogels and Nanoparti...mentioning

confidence: 99%

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

Yin,

Liang,

Han

et al. 2023

Small Methods

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Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as a loss of motor and sensory functions. Inhibition of injury expansion and even reversal of injury in the acute damage stage of SCI are important strategies for treating this disease. Hydrogels and nanoparticle (NP)‐based drugs are the most effective, widely studied, and clinically valuable therapeutic strategies in the field of repair and regeneration. Hydrogels are 3D flow structures that fill the pathological gaps in SCI and provide a microenvironment similar to that of the spinal cord extracellular matrix for nerve cell regeneration. NP‐based drugs can easily penetrate the blood‐spinal cord barrier, target SCI lesions, and are noninvasive. Hydrogels and NPs as drug carriers can be loaded with various drugs and biological therapeutic factors for slow release in SCI lesions. They help drugs function more efficiently by exerting anti‐inflammatory, antioxidant, and nerve regeneration effects to promote the recovery of neurological function. In this review, the use of hydrogels and NPs as drug carriers and the role of both in the repair of SCI are discussed to provide a multimodal strategic reference for nerve repair and regeneration after SCI.

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An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment

Cited by 12 publications

References 45 publications

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

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