Sombor index is a newly developed degree-based topological index which involves the degree of the vertex in a simple connected graph. The Sombor index is known as the square root of the sum of the squared degrees of two adjacent vertices in a graph. Meanwhile, the noncommuting graph associated to a group is a graph where its vertices are the non-central elements of the group and two vertices are adjacent if and only if they do not commute. In this study, a new notion called the Sombor polynomial is introduced. Then, the general formula of the Sombor index and the Sombor polynomial of the noncommuting graph associated to some finite groups are determined by using their definitions and some preliminaries. The groups involved in this research are the dihedral groups, the quasidihedral groups, and the generalized quaternion groups. The results found can help the chemists and biologists to predict the chemical and physical properties of the molecules without involving any laboratory work.