An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications

Goswami, Aakansha Giri; Basu, Somprakas; Huda, Farhanul; Pant, Jayanti; Kar, Amrita Ghosh; Banerjee, Tuhina; Shukla, Vijay Kumar

doi:10.1080/08977194.2022.2074843

Cited by 23 publications

(12 citation statements)

References 110 publications

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“…Various GFs in PRP, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), are major contributors to its capability of promoting wound healing. VEGF is known as a key dynamic molecule of angiogenesis [ 34 ]. PDGF participates in inflammation, granulation tissue formation, reepithelialization, matrix formation and remodelling [ 3 ].…”

Section: Resultsmentioning

confidence: 99%

Pre-clinical evaluation of thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network hydrogel for wound healing

Tang¹,

Li²,

Han³

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Pre-clinical evaluation of thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network hydrogel for wound healing

Tang¹,

Li²,

Han³

et al. 2022

Materials Today Bio

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“…The diabetic wounds have become one of the main types of wounds in clinic. The impaired healing of diabetic wounds is mainly characterized by long-term severe inflammation, insufficient and low-activity growth factors, difficult to vascularization, excessive ROS, and easy infection (Goswami et al, 2022). Minor defects of diabetic skin can often be healed by drugs, growth factors, dressings, and other methods.…”

Section: Discussionmentioning

confidence: 99%

Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction

Wang

Lin

et al. 2023

Front. Bioeng. Biotechnol.

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The tissue reconstruction of diabetic wounds mainly depends on the proliferation and remodelling of cutaneous cells around wounds and the transplantation of random skin flaps, however, the proliferation of cells or survival of skin flaps are difficult due to the severe inflammation and other problems caused by diabetes. The stem cell-derived exosomes loaded with miRNA can be an effective therapeutic strategy for promoting diabetic wound healing. Therefore, in this study, the engineered exosomes derived from miR-132-overexpressing adipose stem cells (miR-132-exo) was obtained for promoting the healing of diabetic wounds and skin flaps. In vitro, the miR-132-exo promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs). In vivo, streptozotocin (STZ) induced diabetic mice were used to create full-thickness skin wounds and random skin flaps to further investigate the healing effect of miR-132-exo. The results showed miR-132-exo evidently enhanced the survival of skin flaps and promote diabetic wound healing, through reducing local inflammation, promoting angiogenesis and stimulating M2-macrophages polarization mediated by NF-κB signaling pathway. These novel findings demonstrated that engineered miR-132-exo can be a potent therapeutic for treating diabetic wounds and inflammatory-related disease.

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“…HIF-1 has been reported to be involved in the process of angiogenesis through wound healing [ 59 ]. Further, VEGF is a strong stimulus for wound healing through angiogenesis, in addition to collagen deposition and epithelialization [ 60 ]. In general, bee venom has been reported to enhance angiogenesis via increasing the VEGF expression [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds

Alamoudi

Alharbi

Abdel-Naim

et al. 2022

Life

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Diabetic hyperglycemia delays wound healing, leading to serious consequences. Topical antibiotics can reduce the risk of a wound infection during healing; nevertheless, the microbial fight against antibiotics brings about public health challenges. Anti-microbial peptides (AMPs) belong to a novel class of drug that is used to prevent and treat systemic and topical infections. The aim of the current work was to achieve better wound healing in diabetic rats by conjugating the anti-microbial peptide “apamin” (APA) with the broad-spectrum antibiotic “ceftriaxone” (CTX) to form a nanocomplex. The CTX–APA nanoconjugate formulation was optimized using a Box–Behnken design. The optimized CTX–APA nanoconjugate formulation was evaluated for its size and zeta potential, and was then examined using transmission electron microscopy (TEM). The CTX–APA nanoconjugate was loaded onto a hydroxypropyl methylcellulose (2% w/v)-based hydrogel. It was observed that the application of the CTX–APA nanocomplex on the wounded skin of diabetic rats accelerated the regeneration of the epithelium, granulation tissue formation, epidermal proliferation, and keratinization. The nanocomplex was capable of significantly reducing the expression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), while increasing the expression of transforming growth factor beta-1 (TGF-β1) as well as the angiogenic markers: hypoxia-inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor (VEGF). Conclusively, the application of an ion-paired CTX–APA nanocomplex enhances wound healing in diabetic rats.

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An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications

Cited by 23 publications

References 110 publications

Pre-clinical evaluation of thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network hydrogel for wound healing

Pre-clinical evaluation of thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network hydrogel for wound healing

Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction

Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds

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