An apprise on novel drug delivery systems for management of diabetes mellitus

Pardhi, Ekta; Bhor, Yojana; Singh, Pankaj Kumar; Mehra, Neelesh Kumar

doi:10.1016/j.jddst.2024.105473

Journal of Drug Delivery Science and Technology

2024

DOI: 10.1016/j.jddst.2024.105473

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An apprise on novel drug delivery systems for management of diabetes mellitus

Ekta Pardhi,

Yojana Bhor,

Pankaj Kumar Singh

et al.

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2024

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Cited by 3 publications

References 158 publications

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Advances in the study of the biological activity of polysaccharide-based carbon dots: A review

Yao,

Zhou,

Cai

et al. 2024

International Journal of Biological Macromolecules

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Advances in the study of the biological activity of polysaccharide-based carbon dots: A review

Yao,

Zhou,

Cai

et al. 2024

International Journal of Biological Macromolecules

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Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity

Kole,

Jadhav,

Khan

et al. 2024

Futur J Pharm Sci

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Background Vildagliptin (VLG), an antidiabetic agent, presents a potential solution to this widespread affliction. It exhibits notable attributes, such as a high solubility and a shorter elimination half-life. The current study uses a microreactor to fabricate sustained-release VLG-encapsulated cross-linked chitosan–dextran sulfate nanoparticles (VLG-CDNPs). The fabrication was systematically optimized using the design of experiment approach. Results The optimized VLG-CDNPs had an average particle size of 217.4 ± 12.3 nm and an encapsulation efficiency of 78.25 ± 3.0%. Scanning electron microscopy revealed that the nanoparticles had a smooth spherical shape. Spray drying was used for drying, and the reconstitution ability was close to ideal (~ 1.33). In vitro studies revealed sustained VLG release over 12 h, with ~ 58% in acidic and ~ 83% in basic conditions. Cell viability remained at 80% even at 100 μg/mL, and glucose uptake in L6 cells was significantly enhanced with VLG-CDNPs (78.34%) compared to pure VLG (60.91%). VLG-CDNPs also showed moderate inhibitory activity against α-amylase (41.57%) and α-glucosidase (63.48%) compared to pure VLG, which had higher inhibition levels. Conclusion The study’s outcome suggested that the optimized VLG-CDNPs may serve as an effective and promising nanoformulation for managing diabetes mellitus.

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Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

Vasileva,

Gaynanova,

Romanova

et al. 2024

RUSS CHEM REV

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Diabetes and complications derived are among serious global health concerns that critically deteriorate the quality of patient life and in some cases result in lethal outcome. Herein, general information on the pathogenesis, factors aggravating the course of the disease and drugs used for the treatment of two types of diabetes are briefly discussed. The aim of the review is to introduce supramolecular strategies that are currently being developed for the treatment of diabetes mellitus and are very effective alternative to chemical synthesis, which allows for fabrication of nanocontainers with switchable characteristics answering green chemistry criteria. Particular attention is paid to organic (amphiphilic and polymeric) formulations, including naturally driven compositions due to their biocompatibility, low toxicity, and bioavailability. Advantages and limitations of different nanosystems are discussed, with their adaptivity to noninvasive administration routes emphasized. <br> The bibliography includes 378 references.

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An apprise on novel drug delivery systems for management of diabetes mellitus

Cited by 3 publications

References 158 publications

Advances in the study of the biological activity of polysaccharide-based carbon dots: A review

Advances in the study of the biological activity of polysaccharide-based carbon dots: A review

Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity

Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

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