Rotor blades experience unsteady forces and aerodynamic losses when operating in a distorted inflow. The structural analysis of rotors under these conditions, therefore, is of prime importance during the early design phase. In a companion paper, an extension to the multi-meanline method for conceptual fan stage design in a non-axisymmetric flow field has been presented. Here, the authors present a computationally efficient design framework that links the aerodynamic design and structural analysis of the rotor. Rotor structural analysis comprises of computing dynamic stresses, the excitation frequencies, and resonance margins at various modes of vibration. A design space encapsulating fan stage design variables, aerodynamic performance, and rotor structural constraints is explored and optimized for maximum fan stage efficiency subject to aerodynamic and mechanical constraints.