Advanced Mathematics is an important basic course in science and engineering colleges. It is widely used in many fields, such as natural science, engineering technology, life science, social science, economic management, etc. Because of its high abstraction and strict logic, students' learning enthusiasm is not high, their goals are unclear, and the teaching effect is not ideal. In view of the above situation, this paper analyzes the present situation of higher mathematics teaching from the perspective of college students' learning foundation, learning attitude, teaching material content and the significance of the research on higher mathematics teaching methods under the background of innovation and entrepreneurship education, and focuses on the different teaching concepts of the innovative mode of higher mathematics. In view of the existing problems, this article proposes that some countermeasures for the innovation of higher mathematics teaching so as to offer help and reference for educators in colleges and universities. It is mainly hoped that innovative teaching methods, means and ideas of higher mathematics can be integrated into it, which will help the sustainable development of higher education and make it more perfect and novel, thus helping to give full play to the leading role of teachers, mobilize students' enthusiasm and initiative in learning, and achieve the purpose of improving teaching effect and students' learning effect.