Cardiovascular disease is the main cause of death worldwide. The World Health Organization (WHO) reports that 17.9 million individuals die yearly due to complications from heart disease and other heart-related ailments. ECG monitoring and early detection are critical to decreasing myocardial infarction (MI) mortality. Thus, a non-invasive method to accurately classify different types of MI would be extremely beneficial. Our proposed study aims to detect and classify Anterior and Inferior MI infarction with advanced deep and machine learning techniques. A newly created UWB radar signal-based image dataset is used to conduct our study experiments. A novel Convolutional spatial Feature Engineering (CSFE) technique is proposed to extract the spatial features from the image dataset. The spatial features consist of both spatial and temporal information which allows machine learning models to leverage both the spatial and temporal relationships present in the data. Study results show that using the proposed CSFE technique, the advanced machine learning techniques achieved high-performance accuracy scores. The K-Neighbors Classifier (KNC) outperformed with a high-performance accuracy score of 98% for detecting Anterior and Inferior patients. The applied methods are fully hyperparametric tuned, and performance is validated using the k-fold cross-validation method.INDEX TERMS Cardiovascular disease, anterior and inferior, MI infarction, UWB radar, machine learning, transfer learning.