An approach to synthesis of (Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)

Weng, Yi Yi; Li, Jian Jun; Su, Weike

doi:10.1016/j.cclet.2011.07.006

Cited by 5 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, BTC/DMF (bis(trichloromethyl) carbonate/ N , N -dimethylformamide) adduct was used in 2007 as a Vilsmeier reagent for the effective synthesis of ( Z )-2-chloro-1,3-diarylpropen-1-ones 124 from 2,3-epoxy-l,3-diarylpropan-1-ones 123, which were readily obtained by oxidation of chalcones using hydrogen peroxide as an oxidant ( Scheme 60 ). 160 The availability of starting materials and simplicity of manipulation make the present protocol a complement for an attractive synthetic method for academic research and potential applications.…”

Section: Dmf As a Reagentmentioning

confidence: 99%

Beyond a solvent: triple roles of dimethylformamide in organic chemistry

2018

View full text Add to dashboard Cite

N,N-Dimethylformamide (DMF) is frequently used as an aprotic solvent in chemical transformations in laboratories of academia as well as in those of chemical industry. In the present review, we will reveal that DMF is actually something much more than a solvent. It is a unique chemical since, as well as being an effective polar aprotic solvent, it can play three other important roles in organic chemistry. It can be used as a reagent, a catalyst, and a stabilizer.

show abstract

Section: Dmf As a Reagentmentioning

confidence: 99%

Beyond a solvent: triple roles of dimethylformamide in organic chemistry

2018

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: An Approach to Synthesis of (Z)‐2‐Chloro‐1,3‐diarylpropen‐1‐ones by Vilsmeier Reagent (Bis‐(trichloromethyl) carbonate/DMF).

Weng

2012

ChemInform

View full text Add to dashboard Cite

show abstract

α‐Substituted Chalcones: A Key Review

Al-Rifai

Mubarak

2021

ChemistrySelect

View full text Add to dashboard Cite

Chalcones are attractive chemical motifs with various biological activities. Aryl substituted chalcones have been extensively studied and reviewed through the years. However, α‐substituted chalcones have rarely been investigated. Hence, this review highlights the α‐substituted chalcones: their synthetic routes, reported biological activities, and transformations to other organic compounds. To the best of our knowledge, this would be the first comprehensive review about α‐substituted chalcones. α‐Substitution of chalcones represents a promising approach to tune their reactivity since it has a direct influence on their activity as Michael acceptors. Additionally, α‐substitution has its effect on the structure and conformation of chalcones. Altering the reactivity of chalcones by α‐substitution has a great impact on their biological activity.

show abstract

An approach to synthesis of (Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)

Cited by 5 publications

References 20 publications

Beyond a solvent: triple roles of dimethylformamide in organic chemistry

Beyond a solvent: triple roles of dimethylformamide in organic chemistry

ChemInform Abstract: An Approach to Synthesis of (Z)‐2‐Chloro‐1,3‐diarylpropen‐1‐ones by Vilsmeier Reagent (Bis‐(trichloromethyl) carbonate/DMF).

α‐Substituted Chalcones: A Key Review

Contact Info

Product

Resources

About