An Approach Toward Assessing Head-and-Neck Lymphedema Using Tissue Dielectric Constant Ratios: Method and Normal Reference Values

Mayrovitz, Harvey N.; Patel, Ashini; Kavadi, Raj; Khan, Zara Ahmad; Bartolone, Samantha

doi:10.1089/lrb.2020.0107

Cited by 13 publications

(14 citation statements)

References 33 publications

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“…This method was utilized alongside tape measurements in the ALOHA Protocol published by Purcell et al and, on initial validity testing in a small sample, did demonstrate a high level of discrimination between patients with HNL and healthy controls, though no confirmatory studies have since been performed in larger samples 25,57 . A recent small study by Mayrovitz et al defined a set of TDC normal ranges for the head and neck in healthy controls 59 . Proponents of TDC measurement recommend its use for the diagnosis of external HNL in patients where the clinical diagnosis is unclear, for classification, with TDC scores correlated to lymphedema severity, and for monitoring over time; its validity for these purposes, especially relative to more sophisticated investigations, remains doubtful 27 …”

Section: Resultsmentioning

confidence: 99%

“…25,57 A recent small study by Mayrovitz et al defined a set of TDC normal ranges for the head and neck in healthy controls. 59 Proponents of TDC measurement recommend its use for the diagnosis of external HNL in patients where the clinical diagnosis is unclear, for classification, with TDC scores correlated to lymphedema severity, and for monitoring over time; its validity for these purposes, especially relative to more sophisticated investigations, remains doubtful. 27 Another bedside technology utilized in a handful of papers is 3D scanning of the head and neck.…”

Section: Technical/imaging-based Assessment Methodsmentioning

confidence: 99%

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Systematic review of head and neck lymphedema assessment

et al. 2022

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Head and neck lymphedema (HNL) is an increasingly recognized complication of head and neck cancer and its treatment. However, no consensus exists on the "gold-standard" assessment tool for the purposes of diagnosis, classification, or monitoring of HNL. We conducted a systematic review of the literature regarding HNL assessment to determine the optimal method/s of assessment for patients with HNL. A review of publications between January 2000 and September 2021 was undertaken on four electronic databases. Studies were excluded if no clear assessment method of HNL was documented. Sixty-seven articles were included in the study. A wide range of assessment methods for HNL have been reported in the literature. For the purposes of diagnosis and classification of physical findings, computed tomography (CT) appears the most promising tool available for both external and internal HNL. In terms of monitoring, ultrasound appears optimal for external HNL, while a clinicianreported rating scale on laryngoscopy is the gold standard for internal HNL.

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Section: Resultsmentioning

confidence: 99%

Section: Technical/imaging-based Assessment Methodsmentioning

confidence: 99%

Systematic review of head and neck lymphedema assessment

et al. 2022

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“…A tissue dielectric constant measurement to determine the %water content at different local points, with the device MoistureMeterD Compact of Delfin [ 36 , 37 ]. 6 points bilateral in the head and neck area (and 1 point submental) are measured according to the protocol “Lymphscanner/MoistureMeter head and neck area” of C.R.…”

Section: Discussionmentioning

confidence: 99%

EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

Aperen

Groef

Devoogdt

et al. 2023

Trials

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Background With over 500,000 annually reported cases worldwide, head and neck cancer (HNC) is the seventh most common type of cancer worldwide. Treatment of HNC with chemoradiotherapy frequently results in serious impairments in physical and psychosocial functioning. Besides, HNC patients typically start their cancer treatment already with poor physical and psychosocial health. It has been shown that a sufficient level of physical activity (PA) before, during, and after cancer treatment is associated with fewer negative treatment-related side effects and a better quality of life (QOL). In order to prevent worsening of functioning and limit the physical impact of the HNC treatment, a comprehensive supervised exercise program (CSEP) may be beneficial during early cancer treatment. However, up to now, the feasibility and effectiveness of such a program are not yet investigated thoroughly in HNC. Therefore, the primary objective of this study is to examine the effectiveness of a CSEP during HNC treatment, in addition to usual supportive care, compared to usual supportive care alone, on health-related QOL up to 1 year post-diagnosis. Secondary objectives entail gathering information on (1) the effectiveness of a CSEP on secondary outcomes such as physical and mental function, activities of daily life, and participation in society and (2) the feasibility, possible barriers, and facilitators for participation in a CSEP during HNC treatment. Methods To investigate the effectiveness of the CSEP, a parallel, open-label randomized controlled trial will be performed. To study the feasibility of the CSEP, a mixed-method study will be performed in a subgroup of participants. HNC patients are eligible if they receive radiotherapy at the Radiation-Oncology department of the University Hospital of Leuven. A 4-size permuted block randomization will be used. The control group receives the current standard of supportive care. The intervention group receives a CSEP, additional to the same usual supportive care. The CSEP consists of a 12-week intensive phase with 3 exercise sessions of 1 h per week, where supervision is gradually reduced after 6 weeks. During the maintenance phase (from week 13), patients exercise at home with monthly tele-consultations with a physiotherapist. The CSEP contains supervised aerobic and resistance training. In both groups, outcomes of interest are evaluated through self-reported questionnaires and clinical assessments, at baseline, 6 weeks, 12 weeks, 6 months, and 12 months post-diagnosis. The primary endpoint is health-related QOL, measured with the EORTC QLQ-C30 at 6 months post-diagnosis. Discussion The study will be conducted in accordance with the Declaration of Helsinki. This protocol has been approved by the ethical committee of the University Hospitals Leuven (s65549). Recruitment started in January 2022. Results will be disseminated via peer-reviewed scientific journals and presentations at congresses. Trial registration Trial Registration: ClinicalTrials.gov Identifier: NCT05256238 Date of registration: February 25, 2022

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“…External lymphedema A tissue dielectric constant measurement to determine the %water content at different local points, with the device MoistureMeterD Compact of Delfin (36,37). 6 points bilateral in the head and neck area (and 1 point submental) are measured according to the protocol "Lymphscanner/MoistureMeter head and neck area" of C.R.…”

Section: X X X Xmentioning

confidence: 99%

EffEx-HN Trial: Study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

Aperen

Groef

Devoogdt

et al. 2023

Preprint

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Background With over 500 000 annually reported cases worldwide, head and neck cancer (HNC) is the seventh most common type of cancer worldwide. Treatment of HNC with chemoradiotherapy frequently results in serious impairments in physical and psychosocial functioning. Besides, HNC patients typically start their cancer treatment already with poor physical and psychosocial health. It has been shown that a sufficient level of physical activity (PA) before, during and after cancer treatment is associated with fewer negative treatmentrelated side effects and a better quality of life (QOL). In order to prevent worsening of functioning and limit the physical impact of the HNC treatment, a comprehensive supervised exercise program (CSEP) may be beneficial during early cancer treatment. However, up to now, the feasibility and effectiveness of such a program are not yet investigated thoroughly in HNC. Therefore, the primary objective of this study is to examine the effectiveness of a CSEP during HNC treatment, in addition to usual supportive care, compared to usual supportive care alone, on health-related QOL up to 1 year post-diagnosis. Secondary objectives entail gathering information on 1) the effectiveness of a CSEP on secondary outcomes such as physical and mental function, activities of daily life and participation in society, 2) the feasibility, possible barriers and facilitators for participation in a CSEP during HNC treatment. Methods To investigate the effectiveness of the CSEP, a parallel, open-label randomized controlled trial will be performed. To study the feasibility of the CSEP, a mixed-method study will be performed in a subgroup of participants. HNC patients are eligible if they receive radiotherapy at the Radiation-Oncology department of the University Hospital of Leuven. A 4-size permuted block randomization will be used. The control group receives the current standard of supportive care. The intervention group receives a CSEP, additional to the same usual supportive care. The CSEP consists of a 12-week intensive phase with 3 exercise sessions of 1-hour per week, where supervision is gradually reduced after 6 weeks. During the maintenance phase (from week 13), patients exercise at home with monthly teleconsultations with a physiotherapist. The CSEP contains supervised aerobic and resistance training. In both groups, outcomes of interest are evaluated through self-reported questionnaires and clinical assessments, at baseline, 6 weeks, 12 weeks, 6 months and 12 months post-diagnosis. The primary endpoint is health-related QoL, measured with the EORTC QLQ-C30 at 6 months post-diagnosis. Discussion The study will be conducted in accordance with the Declaration of Helsinki. This protocol has been approved by the ethical committee of the University Hospitals Leuven (s65549). 3 Recruitment started in January 2022. Results will be disseminated via peer-reviewed scientific journals and presentations at congresses. Trial Registration: ClinicalTrials.gov Identifier: NCT05256238 Date of registration: February 25, 2022

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An Approach Toward Assessing Head-and-Neck Lymphedema Using Tissue Dielectric Constant Ratios: Method and Normal Reference Values

Cited by 13 publications

References 33 publications

Systematic review of head and neck lymphedema assessment

Systematic review of head and neck lymphedema assessment

EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

EffEx-HN Trial: Study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life

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