Considering the intertwining of information technology and engineering specialty courses, research on the application of the "Five-in-one" teaching mode based on building information modeling (BIM) in the teaching of engineering specialty courses is practical and significant. This article comprehensively analyzes the research status of the teaching mode of engineering courses in China and the integration of BIM in the teaching of specialized courses. On the basis of the personnel cultivating programs for various engineering majors in combination with the three-dimensional information model, BIM, this study proposed the "Five-in-one" teaching mode covering aspects of scenario creation, new knowledge exploration, knowledge application, thinking training, and teamwork. This teaching mode is adaptable to the reform of engineering classroom teaching and it complements professional talent training goals. The "Five-in-one" teaching mode guides students to learn to choose and develop actively, enabling them to become the core of the classroom. The academic performances of students are studied using variance and covariance analysis models, forming a complete set of analysis results. This study uses the teaching practice of the BIM-based "Five-in-one" teaching mode in the engineering courses of an application-oriented university in Guangxi as an example. The results obtained show that this method achieved good results. The students' mastery of basic knowledge, basic skills, and basic thinking methods of the subject improved significantly. Thus, theoretical references for the practice and research of the teaching mode of professional courses for application-oriented universities at home and abroad have been provided.