An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention

Kandeda, Antoine Kavaye; Nodeina, Saleh; Mabou, Symphorien Talom

doi:10.1007/s11011-022-01052-y

Cited by 4 publications

(6 citation statements)

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“…In the development of TLE, the involvement of OS and neuroinflammation have been well established as important factors, in part because the large amount of energy required by the brain is considered to be a possible mechanism involved in epileptogenesis [ 12 , 21 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. In recent studies, it was observed that the specific inhibition of NADPH oxidase (NOX), the main producer of OS through O 2 •− synthesis, modified chronic epilepsy in a TLE rat model, preventing ROS generation, mitochondrial depolarization, and neuronal death.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

et al. 2023

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Epilepsy is a neurological disorder in which it has been shown that the presence of oxidative stress (OS) is implicated in epileptogenesis. The literature has shown that some antiseizure drugs (ASD) have neuroprotective properties. Levetiracetam (LEV) is a drug commonly used as an ASD, and in some studies, it has been found to possess antioxidant properties. Because the antioxidant effects of LEV have not been demonstrated in the chronic phase of epilepsy, the objective of this study was to evaluate, for the first time, the effects of LEV on the oxidant–antioxidant status in the hippocampus of rats with temporal lobe epilepsy (TLE). The in vitro scavenging capacity of LEV was evaluated. LEV administration in rats with TLE significantly increased superoxide dismutase (SOD) activity, increased catalase (CAT) activity, but did not change glutathione peroxidase (GPx) activity, and significantly decreased glutathione reductase (GR) activity in comparison with epileptic rats. LEV administration in rats with TLE significantly reduced hydrogen peroxide (H2O2) levels but did not change lipoperoxidation and carbonylated protein levels in comparison with epileptic rats. In addition, LEV showed in vitro scavenging activity against hydroxyl radical (HO•). LEV showed significant antioxidant effects in relation to restoring the redox balance in the hippocampus of rats with TLE. In vitro, LEV demonstrated direct antioxidant activity against HO•.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

et al. 2023

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“…During epileptogenesis, memory and emotion are particularly altered because they share the same anatomical structure with TLE. This explains why working memory impairment and anxiety disorders are common complaints in patients with TLE ( Kandeda et al, 2021b ; Kandeda et al, 2022c ; Kandeda et al, 2022d ). Thus, a drug that can prevent or inhibit the development of these neuropsychiatric disorders, in people at risk, is of interest ( Singh et al, 2021 ; Pollo et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“… Vogt et al (2022) reported similar cognitive and behavioral impairments following a chronic injection of PTZ in rodents. Indeed, PTZ-kindling provides the opportunity to study associated cognitive deficits ( Singh et al, 2018 ; de Souza et al, 2019 ; Kandeda et al, 2022d ). Furthermore, during the open field test, PTZ-kindling led to a decrease in anxiety-like behavior in the PTZ group.…”

Section: Discussionmentioning

confidence: 99%

“…These results are consistent with those of Temp et al (2017) and Hoda et al (2017) who showed a similar variation following chronic PTZ injections in rats. PTZ can activate microglia and induce the release of TNF-α, IL-1β, and IL-6 ( Kandeda et al, 2022d ). These cytokines can increase glutamate level and stimulate endocytosis of GABA receptors ( Temp et al, 2017 ; Sharma et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Structural changes, infections, genetic mechanisms, immune factors, and metabolic activities, alone or in combination, can lead to epileptogenesis and TLE. At the molecular and cellular levels, numerous reports implicate a deficit in GABA neurotransmission, an increase in oxidative stress, and inflammation as factors associated with neuronal loss in the hippocampus during TLE development ( Hinton and Johnston, 2018 ; Kandeda et al, 2022d ). Behaviorally, these alterations are particularly associated with cognitive and psychiatric disorders such as anxiety disorders and working memory impairment ( Scott et al, 2017 ; Vinti et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Aqueous extract of Parkia biglobosa (Jacq.) R. Br. (Fabaceae) exerts antiepileptogenic, anti-amnesic, and anxiolytic-like effects in mice via mechanisms involving antioxidant and anti-inflammatory pathways

et al. 2022

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Parkia biglobosa (Jacq.) R. Br. (Fabaceae) is a widely distributed tree, used in traditional medicine to treat amebiasis, hookworm infection, ascariasis, asthma, sterility, dental pain, headaches, cardiac disorders, and epilepsy. To date, no study on the effect of an aqueous extract of P. biglobosa on epileptogenesis and associated neuropsychiatric disorders has been undertaken. Therefore, this study aimed to investigate antiepileptogenic-, antiamnesic-, and anxiolytic-like effects of an aqueous extract of P. biglobosa using pentylenetetrazole (PTZ)-induced kindling in mice. Animals were divided into six groups of eight mice each. Thus, a PTZ group received distilled water (10 ml/kg, per os), a positive control group received sodium valproate (300 mg/kg, p.o.), and three test groups received the aqueous extract of P. biglobosa (80, 160, and 320 mg/kg, p.o.).In addition, a control group of eight mice receiving distilled water (10 ml/kg, p.o.) was formed. The treatments were administered to mice, 60 min before administration of PTZ (20 mg/kg, i.p.). These co-administrations were performed once daily, for 22 days. The number and duration of seizures (stages 1, 2, 3, and 4 of seizures) exhibited by each mouse were assessed for 30 min during the treatment period. Twenty-four hours following the last administration of the treatments and PTZ, novel object recognition and T-maze tests were performed to assess working memory impairment in mice, while the open field test was performed to assess anxiety-like behavior. After these tests, the animals were sacrificed, and the hippocampi were collected for biochemical and histological analysis. During the period of PTZ-kindling, the extract at all doses completely (p < 0.001) protected all mice against stages 3 and 4 of seizures when compared to sodium valproate, a standard antiepileptic drug. The extract also significantly (p < 0.001) attenuated working memory impairment and anxiety-like behavior. In post-mortem brain analyses, the extract significantly (p < 0.001) increased γ-aminobutyric acid (GABA) level and reduced oxidative stress and inflammation. Histological analysis showed that the aqueous extract attenuated neuronal degeneration/necrosis in the hippocampus. These results suggest that the extract is endowed with antiepileptogenic-, anti-amnesic-, and anxiolytic-like effects. These effects seem to be mediated in part by GABAergic, antioxidant, and anti-inflammatory mechanisms. These results suggest the merit of further studies to isolate the bioactive molecules responsible for these potentially therapeutically relevant effects of the extract.

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Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

He,

Chen,

Yang

et al. 2024

Journal of Ethnopharmacology

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An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention

Cited by 4 publications

References 152 publications

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

Evaluation of the Antioxidant Activity of Levetiracetam in a Temporal Lobe Epilepsy Model

Aqueous extract of Parkia biglobosa (Jacq.) R. Br. (Fabaceae) exerts antiepileptogenic, anti-amnesic, and anxiolytic-like effects in mice via mechanisms involving antioxidant and anti-inflammatory pathways

Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

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