An array of femtoliter wells for sensitive detection of copper using click chemistry

Ge, Chenchen; Chen, Xiong; Wang, Dou

doi:10.1016/j.talanta.2024.125973

Talanta

2024

DOI: 10.1016/j.talanta.2024.125973

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An array of femtoliter wells for sensitive detection of copper using click chemistry

Chenchen Ge,

Xiong Chen,

Dou Wang

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2024

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Cited by 3 publications

References 26 publications

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Biosensing meets click chemistry: A promising combination for analysis of food hazard factors

Zhou,

Zhang,

et al. 2024

Coordination Chemistry Reviews

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Biosensing meets click chemistry: A promising combination for analysis of food hazard factors

Zhou,

Zhang,

et al. 2024

Coordination Chemistry Reviews

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Integrating L-Cys-AuNCs in ZIF-8 with Enhanced Fluorescence and Strengthened Stability for Sensitive Detection of Copper Ions

Zhou,

Zang,

Zhang

et al. 2024

Molecules

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Gold nanoclusters (AuNCs) have been widely investigated because of their unique photoluminescence properties. However, the applications of AuNCs are limited by their poor stability and relatively low fluorescence. In the present work, we developed nanocomposites (L-Cys-AuNCs@ZIF-8) with high fluorescence and stability, which were constructed by encapsulating the water-dispersible L-Cys-AuNCs into a ZIF-8 via Zn2+-triggered growth strategy without high temperature and pressure. The maximum emission wavelength of the L-Cys-AuNCs@ZIF-8 composite was at 868 nm, and the fluorescence intensity of L-Cys-AuNCs@ZIF-8 was nearly nine-fold compared with L-Cys-AuNCs without the ZIF-8 package. The mechanism investigation by fluorescence spectroscopy and X-ray photoelectron spectroscopy showed that L-Cys-AuNCs@ZIF-8 impeded ligand rotation, induced energy dissipation, and diminished the self-quenching effect, attributing to the spatial distribution of L-Cys-AuNCs. Based on the high fluorescence efficiency of L-Cys-AuNCs@ZIF-8, a “signal off” detective platform was proposed with copper ions as a model analyte, achieving a sensitive detection limit of Cu2+ at 16.7 nM. The quenching mechanism was confirmed, showing that the structure of the L-Cys-AuNCs@ZIF-8 nanocomposites was collapsed by the addition of Cu2+. Attributing to the strong adsorption ability between copper ions and pyridyl nitrogen, the as-prepared L-Cys-AuNCs@ZIF-8 was shown to accumulate Cu2+, and the Zn2+ in ZIF-8 was replaced by Cu2+.

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Portable Detection of Copper Ion Using Personal Glucose Meter

Du,

Chen,

Huang

et al. 2024

Sensors

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A simple and sensitive method for Cu2+ detection was developed using the Cu+-catalyzed alkyne–azide cycloaddition reaction, Fe3O4 magnetic nanoparticles (MNPs) as the reaction platform, and a portable blood glucose meter (PGM) as the detection method. Gold nanoparticles (AuNPs) were labeled with glucose oxidase (GOx) and alkyne-functionalized, terminally thiolated ssDNA (C2). In the presence of Cu2+ and ascorbate, the functionalized AuNPs were captured onto MNPs modified with azide-functionalized ssDNA (C1) via the Cu+-catalyzed alkyne–azide cycloaddition reaction. The GOx on the AuNPs’ surface oxidized glucose (Glu) into gluconic acid and H2O2, reducing the Glu content in the reaction solution, which was quantitatively detected by the PGM. Under optimal conditions, the PGM response of the system showed a good linear relationship with the logarithm of Cu2+ concentration in the range of 0.05 to 10.00 μmol/L, with a detection limit of 0.03 μmol/L (3σ). In actual tap water samples, the spiked recovery rate of Cu2+ was between 92.30% and 113.33%, and the relative standard deviation was between 0.14% and 0.34%, meeting the detection requirements for Cu2+ in real water samples.

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An array of femtoliter wells for sensitive detection of copper using click chemistry

Cited by 3 publications

References 26 publications

Biosensing meets click chemistry: A promising combination for analysis of food hazard factors

Biosensing meets click chemistry: A promising combination for analysis of food hazard factors

Integrating L-Cys-AuNCs in ZIF-8 with Enhanced Fluorescence and Strengthened Stability for Sensitive Detection of Copper Ions

Portable Detection of Copper Ion Using Personal Glucose Meter

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