This study proposes a management model by business processes for science parks based on the premises and concept of enterprise architecture (EA). The model offers integrating business processes with activities and information that can be generated by adopting customized information systems to meet the science parks’ needs. The proposed model’s main contributions included EA as a means for shaping and enabling reconfiguration through descriptions of the structures of business processes and information systems that connect these structures, forming business and information architecture frameworks. In association with these frameworks, the managers need to define a coherent set of patterns, policies, procedures, and principles that sustain the business processes integrated with the information systems. As a result of the study, this model can help management execute and control activities related to business processes in the parks through interaction and alignment with the information system intended to facilitate the execution. The model will also lead to greater agility and efficiency in these business processes, considering their specific nature and the relationship with the parks’ actors. As a practical contribution, knowledge of these processes aids the management of the parks in their drive for a competitive advantage by maintaining and developing their management models.