An artificial intelligence–based pipeline for automated detection and localisation of epileptic sources from magnetoencephalography

Abstract

Objective. Magnetoencephalography (MEG) is a powerful non-invasive diagnostic modality for presurgical epilepsy evaluation. However, the clinical utility of MEG mapping for localising epileptic foci is limited by its low efficiency, high labour requirements, and considerable interoperator variability. To address these obstacles, we proposed a novel artificial intelligence–based automated magnetic source imaging (AMSI) pipeline for automated detection and localisation of epileptic sources from MEG data. Approach. To expedite the analysis of clinical MEG data from patients with epilepsy and reduce human bias, we developed an autolabelling method, a deep-learning model based on convolutional neural networks and a hierarchical clustering method based on a perceptual hash algorithm, to enable the coregistration of MEG and magnetic resonance imaging, the detection and clustering of epileptic activity, and the localisation of epileptic sources in a highly automated manner. We tested the capability of the AMSI pipeline by assessing MEG data from 48 epilepsy patients. Main results. The AMSI pipeline was able to rapidly detect interictal epileptiform discharges with 93.31% ± 3.87% precision based on a 35-patient dataset (with sevenfold patientwise cross-validation) and robustly rendered accurate localisation of epileptic activity with a lobar concordance of 87.18% against interictal and ictal stereo-electroencephalography findings in a 13-patient dataset. We also showed that the AMSI pipeline accomplishes the necessary processes and delivers objective results within a much shorter time frame (∼12 min) than traditional manual processes (∼4 h). Significance. The AMSI pipeline promises to facilitate increased utilisation of MEG data in the clinical analysis of patients with epilepsy.

Enhancing Precision in Medical Imaging: A 3D CNN Approach for Fiducial Point Detection in MRI Data

“…Zheng et al [22] propose an AI-based pipeline for automated epileptic source detection from MEG. Their method achieves MEG-MRI co-registration without manual intervention, utilizing an autolabeling technique and a pattern recognition approach.…”

“…However, the study reports mean errors ranging from 3.6028 ± 1.4037 mm to 4.0512 ± 1.736 mm, suggesting potential challenges in precise landmark localization. The Automated Magnetic Source Imaging (AMSI) Pipeline, proposed by Zheng et al [22], offers an AI-based solution for detecting and localizing epileptic sources from MEG data. By combining autolabeling, CNNs, and clustering techniques, the AMSI Pipeline achieves efficient and objective analysis of MEG data.…”