An Asian variant of intravascular lymphoma: unique clinical and pathological manifestation in the gallbladder

Kuroda, N.; Mizobuchi, Masahiro; Shimamura, Yuto; Taniguchi, Yasuyuki; Daibata, Masanori; Miyoshi, Isao; Ichimura, Tsuyoshi; Beppu, Hiroko; Ohara, Masanori; Hirouchi, Takashi; Mizuno, Ken‐ichi; Lee, G. H.

doi:10.1111/j.1600-0463.2007.apm_578.x

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…Aberrant expression of CD3 has been reported previously in instances of PEL, as well as other EBV-positive large B-cell lymphomas(27, 50). In addition to the cases of PEL and PBL, two cases of angiotropic lymphoma were reported in literature (37, 38) and occurred in older individuals.…”

Section: Discussionmentioning

confidence: 99%

Gall Bladder and Extrahepatic Bile Duct Lymphomas: Clinicopathological Observations and Biological Implications

Mani

Climent²,

Colomo³

et al. 2010

American Journal of Surgical Pathology

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Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and one involving common hepatic duct), while five had systemic lymphoma on further work-up. Most patients presented with symptoms mimicking cholecystitis. The most common primary lymphoma types were diffuse large B-cell lymphoma (DLBCL), extranodal marginal zone lymphoma (EMZL), B-lymphoblastic lymphoma (B-LBL) and follicular lymphoma (FL). Two cases had features of lymphomatous polyposis, one a case of FL and the second a case of mantle cell lymphoma (MCL), with disease limited to the mantle zones, so-called in situ MCL. Other rare lymphoma subtypes not previously described in this site included the extracavitary variant of primary effusion lymphoma (PEL) and plasmablastic lymphoma (PBL). Patients with DLBCL and EMZL were older (mean age 75.8 years) than those with other subtypes (mean age 47 years) and more likely to have gallstones (60% vs. 12.5%). A comprehensive literature review revealed 36 primary gall bladder and 16 primary extrahepatic bile duct lymphomas. When compared to primary gall bladder lymphomas, those involving the extrahepatic bile ducts present at a younger age (47 years vs. 63 years) usually with obstructive jaundice, and are less often associated with gallstones (17% vs. 50%) or regional lymph node involvement (6% vs. 31%). In conclusion, primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Gall Bladder and Extrahepatic Bile Duct Lymphomas: Clinicopathological Observations and Biological Implications

Mani

Climent²,

Colomo³

et al. 2010

American Journal of Surgical Pathology

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“…4). Мы согласны с тем, что возможной причиной метаболических нарушений, ведущих к дестабилизации биохимического состава желчи пациентов женского пола, может быть повышение уровня эстрогенов крови, стимулирующих печеноч-ные рецепторы к липопротеину и усиливающих вса-сывание холестерина в кишечнике и его секрецию в желчь [6,9,19].…”

Section: результаты и обсуждениеunclassified

“…По данным аутопсии, камни в ЖП находят у 20% женщин и 8% мужчин, то есть в соотношении 2,5:1 [12]. Другие исследователи сходятся во мнении, что ведущим фактором риска желчного камнеобра-зования является возраст, поскольку у лиц старше 70 лет заболеваемость ЖКБ увеличивается до 40-50% [1,11,19]. При этом механизмы литогенеза в зависимости от пола и возраста остаются еще недо-статочно изученными.…”

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Age and Gender Peculiarities of Development of Gallstone Disease

Хохлачева¹,

Sergeeva²,

Вахрушев³

2016

Arhivʺ vnutr. med.

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Цель. Изучение роли факторов риска в механизмах желчного камнеобразования в зависимости от пола и возраста пациентов.Материал и методы. Обследованы 210 пациентов с I стадией желчнокаменной болезни (ЖКБ). В верификации диагноза использованы ре-зультаты ультразвукового исследования гепатобилиарной системы, многофракционного дуоденального зондирования с последующим ма-кроскопическим, микроскопическим, химическим и физическим исследованием желчи. В порциях «В» и «С» желчи определялась суммарная концентрация желчных кислот, холестерина, с последующим вычислением холатохолестеринового коэффициента. Проведено определение поверхностного натяжения желчи и вязкости желчи. В крови изучено содержание общего холестерина, липопротеидов очень низкой плотно-сти, липопротеидов низкой плотности, липопротеидов высокой плотности, триглицеридов, определялся коэффициент атерогенности. В оцен-ке степени накопления жировой массы тела использовался индекс Кетле. Изучен относительный риск анамнестических факторов риска ЖКБ. Заключение. Полученные данные могут быть использованы в организации диспансерной работы с больными гепатобилиарной патоло-гией и в оптимизации первичной профилактики желчного камнеобразования. Ключевые слова: факторы риска желчного камнеобразования, литогенная желчь, возрастно-половые особенности холецистолитиаза AbstractGoal. Study of the role of risk factors in mechanized gall stone formation depending on sex and age of patients. Material and methodsWe examined 210 patients with stage I gallstone disease (GSD). In verification of diagnosis used an ultrasound study of the hepatobiliary system, multi-grade duodenal sounding with subsequent macroscopic, microscopic, chemical and physical examination of bile. In the portions "b" and "C" bile was determined the total concentration of bile acids, cholesterol, with the subsequent calculation it consists of cholesterol ratio. Estimation of surface tension of bile viscosity and bile. In the studied blood levels of total cholesterol, lipoproteins of very low density, lowdensity lipoproteins, high density lipoproteins, triglycerides, were determined the coefficient of atherogenicity. To assess the degree of accumulation of body fat was used the Quetelet index. Studied the relative risk of anamnestic risk factors of GSD.Results. The features of biliary lithogenesis based on gender and age of patients. High value PR for the gall stone formation are female gender -3,16, Mature and elderly age (older than 50) of 3.67. In young women, gall-stone formation is mainly due to the increase of cholesterol level of bile, at the age of 50 years with a decline in zhelchnokamennaja pool, increased viscosity and surface tension of bile.The most important risk factors of cholecystolithiasis are also gender differences: if women is multiple pregnancies and (or) childbirth (more than 3) -OR 4,62, overweight (BMI over 26) -OR is 4.57 and the violation of the principles of good nutrition (eating disorders, overeating or starvation, the use of large quantities of animal fats) -OR 3,94, for men it's...

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Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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The gallbladder is involved by a wide variety of non-epithelial tumors, apart from mesenchymal neoplasms. Visceral malignant melanoma develops in the biliary tract, including the gallbladder. As both primary and metastatic gallbladder melanomas may show similar of the same growth patterns, the differential diagnosis between these two conditions is often difficult. Primary gallbladder melanoma is more likely if the tumor shows a polypoid or lobulated and in particular papillary growth pattern, is a solitary lesion, and is associated with junctional activity in the adjacent mucosa. In contrast, metastatic lesions are more commonly multiple, flat, and without junctional changes. Apart from neuroendocrine tumors, other neuroectodermal neoplasms can develop as primary tumors in the gallbladder. Rare primary neoplasms in this organ include germ cell tumors, rhabdoid tumors, perivascular epithelioid cell tumors, and hemolymphatic neoplasms. Apart from malignant melanoma, numerous other malignancies can metastasize to the gallbladder, renal cell carcinoma being a particularly common metastasizing tumor. Malignant Melanoma of the Gallbladder Pathogenic Pathways Few melanocytes are present in the normal gallbladder mucosa, and it has been suggested that malignant melanomas take their origin from these cells that have spread from the neural crest to the gallbladder during oncogenesis. Primitive Neuroectodermal Tumor (PNET) of the Gallbladder Differential Diagnosis Differential diagnosis on conventionally stained sections mainly includes other small cell tumors occurring in the gallbladder, e.g., small cell carcinoma or lymphoma. Differential Diagnosis Gallbladder paraganglioma may occur as a component of multiple paragangliomas, involving the common bile duct and the liver in addition to the gallbladder (Ferrell et al. 1990).

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An Asian variant of intravascular lymphoma: unique clinical and pathological manifestation in the gallbladder

Cited by 8 publications

References 12 publications

Gall Bladder and Extrahepatic Bile Duct Lymphomas: Clinicopathological Observations and Biological Implications

Gall Bladder and Extrahepatic Bile Duct Lymphomas: Clinicopathological Observations and Biological Implications

Age and Gender Peculiarities of Development of Gallstone Disease

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

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