An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll‐like receptor 4

Abstract

Despite decades of research, malignant tumors are extremely difficult to eliminate with conventional methods. Although surgical resection potentially eradicates the problem, only a few cases are suitable for operation, and other approaches often involve harmful consequences. Revolutionary methods are desperately needed to improve patient outcomes and diminish harmful side effects. Myeloid-derived suppressor cells (MDSCs), downregulators of the innate and adaptive immune systems, have been widely studied over the past 2 decades. MDSCs inhibit the antitumor immune response by suppressing T cell proliferation, cytokine production, and tumor cell killing. With MDSCs becoming novel targets in cancer therapy, our research has focused on the anti-MDSC function of Asparagus polysaccharide (AP), extracted from asparagus, a traditional Chinese herb. In this study, we have used MDSCs isolated from the spleen of mice with colon cancer as an in vitro model to assess the efficacy of AP. Treatment of MDSCs with AP significantly decreased cell proliferation and induced apoptotic cell death through a toll-like receptor 4 dependent way. Subsequent studies showed that the AP treatment enhanced the expression of Bax and Caspase-9 and inhibited the expression of Bcl-2, suggesting that AP induced apoptosis in the MDSCs via the intrinsic pathway. Altogether, the results showed that AP exhibited a significant anti-MDSC activity and attenuated suppression of the antitumor immune response, thereby indicating its potential use in cancer therapy.

Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms

“…Various effects of MDSCs on target cells have proven to be a critical pathogenic factor in SLE, including dysregulation of T helper type 17 (Th17) cells and differentiation of Treg (Ji et al 2016 ). MDSCs can also induce podocyte injury by increasing the levels of ROS in lupus nephritis (Zhang et al 2018a , b ). In conclusion, investigating the regulation of MDSCs may provide new insights into the therapy of SLE.…”

In vitro antioxidant, anti-inflammatory and anti-cancer activities of methanolic extract of Asparagus horridus grows in North Cyprus Kuzey Kıbrıs da yetişen Asparagus horridus metanolik ekstraktının in-vitro antioksidan, anti-enflamatuar ve anti-kanser aktivitesi

“…In our current study, anti-proliferative effect of A. horridus on B-CPAP cells was observed and it was found that A. horridus extract with 101.24 μg/mL is required to reduce the B-CPAP cell proliferation by half. Based on the vast amount of cytotoxicity and anticancer studies, it has been confirmed that Asparagus species can be used as natural anticancer agent against various types of cancer [6,11,[26][27][28][29][30][31]. In the light of literature sources and our studies, it is concluded that methanol extract of A. horridus could be a potential anticancer agent for both liver and thyroid cancer treatments.…”

Bibliometrics Research on Immune of Traditional Chinese Medicine

“…Wang Y is from Northwest University of Agriculture and Forestry Science and Technology, Li Y from the Dalian University of Technology, Li X from Nanjing University of Traditional Chinese Medicine. They mainly studied the mechanism of immunomodulation [15][16][17] and anti-inflammation [18][19][20] of traditional Chinese medicine. Keeping an eye on the three authors new articles will obtain an update on the immunological research of traditional Chinese medicine (TCM).…”