2020
DOI: 10.1007/s12079-020-00590-3
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An assembly of galanin–galanin receptor signaling network

Abstract: The galanin receptor family of proteins is present throughout the central nervous system and endocrine system. It comprises of three subtypes—GalR1, GalR2, and GalR3; all of which are G‐protein‐coupled receptors. Galanin predominantly acts as an inhibitory, hyper‐polarizing neuromodulator, which has several physiological as well as pathological functions. Galanin has a role in mediating food intake, memory, sexual behavior, nociception and is also associated with diseases such as Alzheimer’s disease, epilepsy,… Show more

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Cited by 16 publications
(22 citation statements)
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“…Human GAL shows subnanomolar affinity at the GAL 1 receptor, subnanomolar to nanomolar affinity at the GAL 2 receptor and tens of nanomolar affinity at the GAL 3 receptor [ 34 ]. Recently, a GAL–GAL receptor signalling network map has been reported that greatly increases the knowledge of the molecules involved in the signalling cascades regulated by the GAL/GAL receptor system [ 35 ]. GAL receptors, with seven transmembrane-domains, are G protein-coupled receptors: GAL 1 receptor is coupled to Gα i and/or Gβγ signalling pathways and mediates the activation of mitogen-activated protein kinases (MAPKs) [ 31 ] ( Figure 2 ).…”
Section: Galaninmentioning
confidence: 99%
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“…Human GAL shows subnanomolar affinity at the GAL 1 receptor, subnanomolar to nanomolar affinity at the GAL 2 receptor and tens of nanomolar affinity at the GAL 3 receptor [ 34 ]. Recently, a GAL–GAL receptor signalling network map has been reported that greatly increases the knowledge of the molecules involved in the signalling cascades regulated by the GAL/GAL receptor system [ 35 ]. GAL receptors, with seven transmembrane-domains, are G protein-coupled receptors: GAL 1 receptor is coupled to Gα i and/or Gβγ signalling pathways and mediates the activation of mitogen-activated protein kinases (MAPKs) [ 31 ] ( Figure 2 ).…”
Section: Galaninmentioning
confidence: 99%
“…In fact, GAL 1 receptor mediates adipogenesis by stimulating MAPK1/MAPK3 activity, via pertussis toxin-sensitive G α inhibitory-subunits, in a Ras/Raf-dependent manner [ 35 ]. Moreover, the activation of the GAL 1 receptor is related to the production of cyclic adenosine monophosphate (cAMP) and adenylyl cyclase [ 35 ] and improves insulin resistance by inhibiting C-reactive protein release and by favouring the AKT/AS160 cascade [ 35 ].…”
Section: Galaninmentioning
confidence: 99%
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