The growing concentration of the population in urban areas presents great challenges for sustainability. Within this process, mobility emerges as one of the main generators of externalities that hinder the achievement of the Sustainable Development Goals. The transition of cities towards innovations in sustainable mobility requires progress in different dimensions, whose interaction requires research. Likewise, it is necessary to establish whether the experiences developed between cities with different contexts can be extrapolated. Therefore, the purpose of this study was to identify how the conditions that determine a city’s readiness to implement urban mobility innovations could be combined. For this, qualitative comparative analysis was applied to a model developed using the multi-level perspective, analyzing 60 cities from different geographical areas and with a different gross domestic product per capita. The R package Set Methods was used. The explanation of the readiness of cities to implement mobility innovations is different to the explanation of the readiness negation. While readiness is explained by two solutions, in which only regime elements appear, the negation of readiness is explained by five possible solutions, showing the interaction between the landscape and regimen elements and enacting the negation of innovations as a necessary condition. The cluster analysis shows us that the results can be extrapolated between cities with different contexts.