An assessment of frequencies of micronucleated erythrocytes in peripheral blood of pigeons (Columba livia Gm) living in the polluted radioactive area around the Siberian chemical plant

Ilyinskikh, N. N.; Ilyinskikh, E. N.; Ksenz, Alexander S.; Yurkin, A. Yu.

doi:10.1016/s0269-7491(97)00098-5

Cited by 7 publications

(5 citation statements)

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“…Moreover, the Tomsk district is of interest because this area contains many industrial sites, for example the Northern industrial unit is located close to Seversk city. More than thirty industrial complexes are located within the Northern industrial unit, including the world's largest nuclear fuel cycle enterprise -the Siberian Chemical Plant (Gauthier-Lafaye et al, 2008;Ilyinskikh et al, 1998;Mezhibor, 2011), and the largest oil and gas processing plant in Russia -Sibur (formerly Tomsk Petrochemical Plant).…”

Section: Studied Areasmentioning

confidence: 99%

“…Bioindication provides information about the direct reaction of organisms, communities or ecosystems to natural or anthropogenic changes (Durkalec et al, 2018), since the biota reacts even to minor changes in external conditions and can even predict the geographical origin (Denisova et al, 2008;Franke et al, 2005;Gauthier-Lafaye et al, 2008;Huang et al, 2017;Ilyinskikh et al, 1998;Sheppard, 2011). The concentration of metals in the body of animals and human beings depends, not only on anthropogenic activity (Durkalec et al, 2018), but also on type of diet (Wang et al, 2014;Zhao et al, 2016), physiological specification of organs and tissues (Carpenè et al, 2017), and genetic characteristics of organism (Demirezen and Uruç, 2006).…”

Section: Introductionmentioning

confidence: 99%

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A regional approach for the calculation of characteristic toxicity factors using the USEtox model

Belyanovskaya

Laratte

Perry

et al. 2019

Science of The Total Environment

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Section: Studied Areasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A regional approach for the calculation of characteristic toxicity factors using the USEtox model

Belyanovskaya

Laratte

Perry

et al. 2019

Science of The Total Environment

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“…The value of this parameter as an indicator for environmental lead pollution has been reported in doves (Hutton M., 1983;Elezaj et al, 2008 ;Selimi et al, 2008). On the other hand common environmental pollutants, together with nuclear radiation, are recognized as genotoxic (Ilyinskikh et al, 1997). Several heavy metals were found to have harmful effects on DNA (Warchalowska-Sliwa, 2005).…”

Section: Introductionmentioning

confidence: 99%

Metal Accumulation, Blood δ-Aminolevulinic Acid Dehydratase Activity and Micronucleated Erythrocytes of Feral pigeons (Columba Livia) Living Near Former Lead-Zinc Smelter “ Trepça” – Kosovo

Elezaj

Selimi

Letaj

et al. 2013

E3S Web of Conferences

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Abstract. The concentration of lead in blood and tibia (Pb), zinc (Zn) and cupper (Cu) in tibia, blood δ -aminolevulinic acid dehydratase (ALA-D; EC: 4.2.1.24) activity, hematocrit value (Hct) and micronuclei frequency (MN) of peripheral erythrocytes have been determinated in three different populations of feral pigeons (Columba livia; forma urbana and forma domestica), collected in Mitrovica town (situated close to smelter "Trepça", down closed in 2000 year ) and in rural area (Koshare willage ) . The blood lead level in feral pigeons from Mitrovica (forma urbana) was 3 times higher (149.6; 50.5 µg%) in comparison with that in feral pigeons from Mitrovica (forma domestica) and 27.7 times higher (5.4 µg% in comparison with pigeons from rural area. The Pb concentration of tibia of feral pigeons (froma urbana and forma domestica), from Mitrovica town was significantly higher (P<0.001) in comparison with control. The concentration of Zn in tibia of feral pigeons from Mitrovica town (forma urbana), was significantly higher (P<0.006) in comparison with control. The blood ALA-D activity of feral pigeons from Mitrovica town (forma urbana and froma domestica), was significantly inhibited in comparison with control. The blood ALA-D activity of feral pigeons -forma urbana from Mitrovica town was significantly inhibited (P<0.001) in comparison with the blood ALA-D activity of feral pigeons-forma domestica from Mitrovica town. The erythrocyte MN frequency of feral pigeons from Mitrovica was significantly higher (P <0.001) in comparison with controls. The smelter "Trepça" ten year after closed down pose a threat to the local environment, biota and people's health.

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“…Interestingly, relatively little attention has been paid so far to wild bird populations in this regard. Although several molecular techniques have been successfully employed in avian studies to evaluate molecular alterations induced by various genotoxic contaminants [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], there is a paucity of work on novel molecular techniques that would allow us to verify the genotoxic properties of lead. Microsatellite instability (MSI) could be potentially effective as such a novel method of detection of genotoxicity of various compounds present in the environment.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite Instability Assay as a Potential Approach to Evaluate Genotoxicity: Lead Exposure in a Nestling Passerine Bird at the Stage of Intensive Erythropoiesis

Markowski

Kaliński

Wawrzyniak

et al. 2023

Animals

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Although many avian studies have investigated the toxic effects of lead on important biochemical and physiological processes, organ and system function, and behavior, studies evaluating the specific genotoxic effects of exposure to lead are scarce. Nowadays, rapid technological advances can provide new molecular techniques in this regard. In this study, as a novel approach in bird studies, we used a panel of ten microsatellite loci to investigate the microsatellite instability (MSI) in response to experimental lead intoxication in a common hole-nesting species, the great tit Parus major. For this purpose, an experiment based on an intentional single supplementation of a lead (II) acetate trihydrate compound was conducted, with the use of two different doses, applied to randomly chosen great tit nestlings from randomly selected broods, being at the stage of intensive erythropoiesis. Although this preliminary study did not find any MSI in the seven microsatellite markers retained for the final comparison, it contributes to the examination of this molecular technique in field conditions as being potentially applicable in ecotoxicological bird studies. We believe that certain issues should be considered in finding an explanation for our result. First, the single doses of lead used in this study may have been too weak to induce genetic instability. Second, the panel of microsatellite markers studied may have been unsusceptible to lead genotoxicity in general. Third, the relatively short time interval (5 days) between the experimental procedure (lead exposure) and the sampling of post-exposure material (blood) for genetic analyses could have limited the effect of lead genotoxicity. Further analyzes are needed to verify these findings and to evaluate the scope of application of the MSI analysis in wild bird population studies.

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An assessment of frequencies of micronucleated erythrocytes in peripheral blood of pigeons (Columba livia Gm) living in the polluted radioactive area around the Siberian chemical plant

Cited by 7 publications

References 1 publication

A regional approach for the calculation of characteristic toxicity factors using the USEtox model

A regional approach for the calculation of characteristic toxicity factors using the USEtox model

Metal Accumulation, Blood δ-Aminolevulinic Acid Dehydratase Activity and Micronucleated Erythrocytes of Feral pigeons (Columba Livia) Living Near Former Lead-Zinc Smelter “ Trepça” – Kosovo

Microsatellite Instability Assay as a Potential Approach to Evaluate Genotoxicity: Lead Exposure in a Nestling Passerine Bird at the Stage of Intensive Erythropoiesis

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