This research investigated the health implications of household water sources in the Kumasi Metropolis, Ghana, analyzing water quality in 23 different households (HS). Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), and spatial distribution analysis were used to uncover valuable insights into the underlying relationships and patterns within the dataset. The findings revealed critical concerns regarding heavy metal concentrations in certain locations: in Appiadu (HS17), both Cu and Pb concentrations exceeded the maximum acceptable limits, suggesting potential Cu and Pb toxicity in household water. Particularly, HS17 exhibited poor water quality, primarily due to high Pb (0.03 mg/L) and Cu (1.65 mg/L) concentrations, surpassing permissible limits set by the World Health Organization (WHO). Moreover, the presence of nitrite in Atonsu Kyepatre (HS13) surpassed the maximum acceptable limit set by the WHO. Conversely, other samples (HS1 – HS16 and HS18 – HS23) demonstrated excellent water quality. The microbial assessment of Ghanaian household water samples unveiled varying counts of total coliforms, indicating potential sewage contamination. Although some sites met acceptable standards for total coliform counts, 13 sites displayed undesirable counts. The health risk estimates revealed that, the hazard quotient (HQ) for Cu ingestion, which revealed values of 2.76 and 1.30 for children and adults, respectively, surpassing the safe limit of 1. Similarly, hazard index (HI) values for adults and children were recorded as 1.79 and 3.80, respectively, indicating significant health risks to consumers. These findings provide valuable insights for other regions facing similar water quality concerns, ensuring the health and well-being of communities worldwide.