An assessment of peripheral vascular disease in patients with diabetic foot ulcer

Ikem, Rosemary; Ikem, IC; Adebayo, Olorunfemi; Soyoye, David

doi:10.1016/j.foot.2010.09.002

Cited by 51 publications

(58 citation statements)

References 17 publications

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“…Age was the risk factor of amputation, the risk factor of systemic atherosclerosis (ASO), and also the risk factor of peripheral vascular disease (PVD) among diabetic patients (7, 8). About 3% of diabetic patients in their 60s had PVD, whereas the percentage was >20% for patients older than 75 (9). The role of age in lower extremity vascular disease is not yet clear, but it is highly possible that vascular biological dynamics change is related to the passage of time, low-density lipoprotein cholesterol, blood pressure, smoking, and blood glucose that has sustained damage on blood vessels, which will eventually lead to vascular ASO (10).…”

Section: Discussionmentioning

confidence: 99%

A study of prognostic factors in Chinese patients with diabetic foot ulcers

Wang¹,

Sun²,

Wang³

et al. 2014

Diabetic Foot & Ankle

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ObjectiveFew studies have identified factors as predictors of clinical prognosis of patients with diabetic foot ulcers (DFUs), especially of Chinese patients. In this study, we assessed the prognostic factors of Chinese patients with DFUs.Methods and materialsThis was a retrospective study (January 2009–January 2011) of 194 DFUs conducted in an inpatient population at PLA 454 Hospital in Nanjing, China, to determine the prognostic influential factors of DFUs in Chinese patients. All of the studied patients were grouped into an amputation group, a non-healing group, and a cured group, according to the clinical prognosis. Patient parameters, including gender, age, smoking habits, education level, family history of diabetes mellitus, medical history, duration of foot lesions and complications, ankle-brachial index (ABI), transcutaneous oxygen pressure (TcPO2), urinary albumin/creatinine ratio (Alb/Cr), fundus oculi, electrocardiogram, DFU characteristics, bacterial nature, and neuropathy, were cross-studied among the three groups.ResultsCompared with the other two groups, the amputation group showed a higher number of males, older in age, lower ABI and TcPO2 levels, higher Wagner wound grading and size, and significantly higher urinary Alb/Cr ratio, blood urea nitrogen, serum creatinine, white blood cell count, and erythrocyte sedimentation rate. Compared to the cured group (162 patients), more patients with an older age, smoking, family history of diabetes mellitus, medical history of foot ulcerations, lower ABI and TcPO2 levels, higher urine Alb/Cr ratio, and serum creatinine were found in the non-healing group. Regression analysis was used to study the correlation between various factors and clinical prognosis, and the results were as follows: age, Wagner wound classification, and heel ulcerations were negatively correlated to the DFU prognosis, whereas the female population, ABI, and TcPO2 were positively correlated with DFU prognosis.ConclusionIn this retrospective study, we conclude that the DFU prognosis may be related to age, gender, wound location (heel), Wagner wound classification, ABI, and TcPO2 levels in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

A study of prognostic factors in Chinese patients with diabetic foot ulcers

Wang¹,

Sun²,

Wang³

et al. 2014

Diabetic Foot & Ankle

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show abstract

“…17 Patients with diabetes who have toe deformities cannot always feel obvious pain or discomfort because of peripheral neuropathy which, over time, becomes resistant to standard therapy. 18 It also becomes difficult for surgeons to determine surgical indications according to symptoms. 19 The abnormally increased plantar pressure observed in the present study might help surgeons to decide whether surgical inventions are necessary in patients with diabetic foot.…”

Section: Discussionmentioning

confidence: 99%

The Characteristics and Clinical Significance of Plantar Pressure Distribution in Patients with Diabetic Toe Deformity: A Dynamic Plantar Pressure Analysis

2011

J Int Med Res

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This study evaluated plantar pressure distribution and its clinical significance in patients with diabetic foot toe deformities. Patients with diabetic claw or hammer toe deformities (patient group; n = 30) and healthy subjects without toe deformities (control group; n = 30) were recruited into the study. Plantar pressures in different regions of the foot were measured using the F-scan ® in-shoe plantar pressure dynamic analysis system. Peak pressures in the hallux and first to fifth metatarsal heads were significantly higher in the patient group compared with the control group. In the midfoot there was no significant difference between the two groups. Hindfoot peak plantar pressures were significantly lower in the patient group compared with the control group. The results indicated that toe deformities in patients with diabetes increased forefoot plantar pressures to abnormally high levels. If plantar pressure is regularly monitored in patients with diabetic foot, toe deformities might be detected earlier and ulceration prevented.

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“…Participants were recruited consecutively, from March to September in 2014, after providing an informed consent. We included those who were: [1] diagnosed with DM and on anti-diabetic therapy, [2] 30 years and older at the time of diagnosis (type 2 DM was more likely in this age group) and, [3] not on steroids or oral contraceptives. The minimum sample size was calculated using a PAD prevalence of 52.5% [23] among patients with DM and a precision of 0.1.…”

Section: Methodsmentioning

confidence: 99%

“…Peripheral arterial disease (PAD) is a chronic complication of diabetes mellitus (DM) and a risk factor for foot ulceration and amputation-more than two-thirds of patients with diabetic foot ulceration have associated PAD [1]. This artheroocclusive disease of the extremities does increase the risk of coronary artery disease as well [2,3].…”

Section: Introductionmentioning

confidence: 99%

Peripheral arterial disease and its correlates in patients with type 2 diabetes mellitus in a teaching hospital in northern Nigeria: a cross-sectional study

Agboghoroma

Akemokwe

Puepet

2020

BMC Cardiovasc Disord

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Background: Peripheral arterial disease (PAD) is a risk factor for diabetic foot ulcer, limb amputation as well as coronary heart disease. It is more common in patients with diabetes mellitus (DM) and co-exists with peripheral neuropathy. Prevalence of PAD in type 2 DM patients in northern Nigeria is largely unknown. We investigated the occurrence and factors associated with PAD among patients with type 2 DM in a tertiary hospital in northern Nigeria. Methods: This was a cross-sectional analytic study. We recruited 200 patients with type 2 DM consecutively from the diabetes clinic of the Jos University Teaching Hospital. Ankle brachial index was assessed for each participant. Clinical information, anthropometric indices and blood samples were collected for assay. Data was analysed using CDC Epi-Info and logistic regression analysis was used to determine independent correlates of PAD. RESULTS:PAD was present in 38.5%(n = 77) of subjects and it was associated with the female sex, age ≥ 50 years, Body mass index (BMI) ≥ 25 kg/m 2 and low HDL cholesterol levels. However, on multiple logistic regression, a BMI ≥ 25 kg/m 2 and a low HDL cholesterol level were independent correlates of PAD(adjusted OR = 2.13,95% CI = 1.04-4.36 and adjusted OR = 2.31, 95% CI = 1.04-5.15, respectively). Conclusion: PAD is present in more than a third of patients with type 2 DM in a tertiary hospital in northern Nigeria. A BMI of ≥25 kg/m 2 and low HDL cholesterol levels were independent correlates of PAD.

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An assessment of peripheral vascular disease in patients with diabetic foot ulcer

Cited by 51 publications

References 17 publications

A study of prognostic factors in Chinese patients with diabetic foot ulcers

A study of prognostic factors in Chinese patients with diabetic foot ulcers

The Characteristics and Clinical Significance of Plantar Pressure Distribution in Patients with Diabetic Toe Deformity: A Dynamic Plantar Pressure Analysis

Peripheral arterial disease and its correlates in patients with type 2 diabetes mellitus in a teaching hospital in northern Nigeria: a cross-sectional study

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