An Assessment of Quality of Life in Patients With Asthma Through Physical, Emotional, Social, and Occupational Aspects. A Cross-Sectional Study

Kharaba, Zelal; Feghali, Emilie; Husseini, Farah El; Sacre, Hala; Selwan, Carla Abou; Saadeh, Sylvia; Hallit, Souheil; Jirjees, Feras; Al-Obaidi, Hala; Salameh, Pascale; Malaeb, Diana

doi:10.3389/fpubh.2022.883784

Cited by 31 publications

(14 citation statements)

References 37 publications

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“…Although psychological stress can exacerbate clinical symptoms in patients with asthma 56 it may have a bidirectional relationship 13 . Prolonged and uncontrolled asthma symptoms can negatively impact the quality of life, including poor psychosocial health 57,58 . However, our study revealed a strong association between early‐life exposure and the high prevalence of asthma symptoms, as evidenced by adverse trajectories throughout childhood.…”

Section: Discussionmentioning

confidence: 62%

Trajectories of psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia

Shahunja,

Sly,

Mamun

2023

Pediatric Pulmonology

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IntroductionSeveral psychosocial factors, such as maternal mental health and parents' financial hardship, are associated with asthma symptoms among children. So, we aim to investigate the changing patterns of important psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia.MethodsWe considered asthma symptoms as wheezing (outcome) and psychosocial environmental factors (exposures) from 0/1 year to 14/15 years of the participants from the “Longitudinal Study of Australian Children (LSAC)” for this study. We used group‐based trajectory modeling to identify the trajectory groups for both exposure and outcome variables. Associations between psychosocial factors and three distinct asthma symptom trajectories were assessed by multivariable logistic regression.ResultsWe included 3917 children from the LSAC birth cohort in our study. We identified distinct trajectories for maternal depression, parents' financial hardship, parents' stressful life events and parents' availability to their children from birth to 14/15 years of age. Compared to the “low/no” asthma symptom trajectory group, children exposed to a “moderate & increasing” maternal depression, “moderate & declining” parents' financial hardship, and “moderate & increasing” parents' stressful life events were significantly associated (relative risk ratio [RRR]: 1.55, 95% confidence interval [CI]: 1.27, 1.91; RRR: 1.40, 95%; CI: 1.15, 1.70; RRR: 1.77, 95%; CI: 1.45, 2.16) with “persistent high” asthma symptom trajectory.ConclusionSeveral psychosocial factors that are potential stressors for mental health increase the risk of having an adverse asthma symptom trajectory during childhood. Further attention should be given to reducing exposure to maternal depression, parents' financial hardship, and parents' stressful live events for long‐term asthma control in children.

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Section: Discussionmentioning

confidence: 62%

Trajectories of psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia

Shahunja,

Sly,

Mamun

2023

Pediatric Pulmonology

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“…Conversely, chronic diseases such as severe asthma may also cause or aggravate affective mood disorders and anxiety in affected patients, who consequentially avoid enjoyable activities and social contacts. 39 , 40 In chronic respiratory diseases, repetitive breathlessness as well as frequent exacerbations can cause a loss of self-control and engulfment of daily routine. Thus, these factors favour mental distress with consecutive depression and anxiety disorder.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between the Response to Antibody Therapy and Symptoms of Depression and Anxiety Disorders in Patients with Severe Asthma

Plank¹,

Hinze²,

Campbell³

et al. 2023

JAA

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Purpose Asthma is associated with a high prevalence of psychopathological disorders, especially depressive disorders or anxiety. In patients with uncontrolled severe asthma, monoclonal antibody (mAb)-therapy positively influenced control of mental disorders. Therefore, we evaluated the impact of antibody therapy on the burden of these mental diseases depending on responder status. Patients and Methods Data were collected retrospectively in patients with uncontrolled severe asthma (n = 82) prior to mAb-therapy (“baseline”) (omalizumab, dupilumab, benralizumab or mepolizumab). Symptoms of Major Depressive Disorder (MDD) or General Anxiety Disorder (GAD) were detected at baseline using the Hospital Anxiety and Depression Scale (HADS), as well as general sociodemographic data and lung function parameters. At 6-month (±3 month) follow-up, the burden of psychopathological symptoms under mAb-therapy was assessed using the Patient Health Questionnaire-2 (PHQ-2) and Generalized Anxiety Disorder Scale-2 (GAD-2). Response status was classified using the Biologics Asthma Response Score (BARS), assessing exacerbations, oral corticosteroid usage and asthma control test (ACT) score. Predictors for non-response to mAb-therapy were identified using linear regression analysis. Results Patients with severe asthma suffered from symptoms of MDD/GAD more often compared to the general population, with a higher prevalence among mAb therapy non-responders. mAb-responders exhibited a declining burden of MDD, better quality of life (QoL), less exacerbations, better lung function and better disease control compared to non-responders. A history of symptoms of depression was identified as a predictor for non-response to mAb-therapy. Conclusion Asthma symptoms and psychological problems are linked and more prevalent in our cohort of severe asthma patients than in the general population. Patients with signs of MDD/GAD before mAb-therapy show less mAb therapy response suggesting a negative impact of prior psychological problems on treatment response. In some patients, the score on MDD/GAD was caused by severe asthma – here symptoms decreased after effective treatment.

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“…Respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are chronic conditions that require an important contribution from patients, society, and the healthcare system [ 1 ]. Moreover, these diseases also play an important role in the patient’s perception of quality of life [ 2 ], although the assessment of well-being related to health is very subjective [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Asthma, COPD, Respiratory, and Allergic Health Effects in an Adult Population Living near an Italian Refinery: A Cross-Sectional Study

et al. 2023

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Background and aim. Asthma and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide. Globally, 545 million people suffer from chronic respiratory diseases with a wide geographical variability. Risk factors for asthma are both genetic and related to several environmental factors (internal and external pollutants); these also have an important role in the occurrence of COPD. The aim of this study was to describe the prevalence of asthma, COPD, and asthma/COPD overlap (ACO) in an adult population living in two municipalities located in the Po Valley. Methods. A standardized questionnaire on respiratory symptoms and sociodemographic characteristics was self-administered to a random sample of the adult population aged 20–64 years, living near a refinery in Northern Italy during the period between 2016 and 2019. Logistic and multinomial regression were implemented to explore factors associated with asthma, COPD, and ACO. Results. In total, 1108 subjects filled out the questionnaire, the mean age was 48.02 ± 12.34 years (range 21–68), and 53% of the respondents/participants were female. Half of the responders were non-smokers, but the frequency of current and former smokers was significantly greater in men than in women (p < 0.001). The likelihood of being a probable case of asthma decreased with increasing age and increased for smokers. Tobacco smoke was associated with the presence of COPD and ACO. Conclusion. Respiratory diseases such as asthma and COPD are common in the general population, with differences among countries worldwide. Our findings show, on the basis of the main confirmed risk factor, namely smoking, that it is useful to plan target programs and actions in order to reduce smoking, thus improving the quality of life in public health.

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An Assessment of Quality of Life in Patients With Asthma Through Physical, Emotional, Social, and Occupational Aspects. A Cross-Sectional Study

Cited by 31 publications

References 37 publications

Trajectories of psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia

Trajectories of psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia

Relationship Between the Response to Antibody Therapy and Symptoms of Depression and Anxiety Disorders in Patients with Severe Asthma

Asthma, COPD, Respiratory, and Allergic Health Effects in an Adult Population Living near an Italian Refinery: A Cross-Sectional Study

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