2022
DOI: 10.3390/jcm11051190
|View full text |Cite
|
Sign up to set email alerts
|

An Assessment of Selected Molecular and Biochemical Markers of the Folate Pathway as Potential Risk Factors for Fetal Trisomy 21 during the First Trimester of Pregnancy in the Polish Population

Abstract: Are the maternal gene variants MTHFR: c.665C>T, MTHFR: c.1286A>C, MTR: c.2756A>G, MTRR: c.66A>G, RFC1: c.80C>T and TCN2: c.776G>C and blood markers of the folate pathway important factors in assessing the risk of fetal trisomy 21 (fetal-T21)? Twenty pregnant women with a high risk and twenty with a low risk of fetal-T21 underwent prenatal examination. Selected gene variants and folate pathway markers and pregnancy-associated plasma protein A (PAPP-A) and free β-subunit of human chorionic gona… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 27 publications
0
1
0
Order By: Relevance
“…Impairment of the methylation pathway leads to the development of neurological disorders such as Alzheimer's disease, autism, Down syndrome, multiple sclerosis; gynecological conditions such as impaired fertility, intrauterine death; as well as immune disorders, cancer, thrombophilia; and cardiovascular diseases such as CAD and ischemic stroke [11][12][13][14][15][16][17][18][19][20][21][22].…”
Section: Overview Of the Methylation Pathwaymentioning
confidence: 99%
“…Impairment of the methylation pathway leads to the development of neurological disorders such as Alzheimer's disease, autism, Down syndrome, multiple sclerosis; gynecological conditions such as impaired fertility, intrauterine death; as well as immune disorders, cancer, thrombophilia; and cardiovascular diseases such as CAD and ischemic stroke [11][12][13][14][15][16][17][18][19][20][21][22].…”
Section: Overview Of the Methylation Pathwaymentioning
confidence: 99%