An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study

Manolakopoulos, Spilios; Bethanis, Sotirios; Liapi, Charis; Stripeli, Fotini; Sklavos, Pantelis; Margeli, Alexandra; Christidou, Aggeliki; Katsanika, Aggeliki; Vogiatzakis, Evangellos; Tzourmakliotis, Dimitrios; Theocharis, Stamatios

doi:10.1186/1471-230x-7-17

Cited by 42 publications

(33 citation statements)

References 41 publications

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“…We found that serum leptin levels were significantly associated with fibrosis in patients with chronic HCV-4 infection. This is in agreement with many previous studies [23,29,30] . In contrast, several other studies have shown no association between serum leptin and fibrosis in HCV infection [31][32][33] .…”

Section: Discussionsupporting

confidence: 83%

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Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

Korah

El-Sayed²,

El-Shafie³

et al. 2013

WJH

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Section: Discussionsupporting

confidence: 83%

“…The behavior of leptin concentrations in the course of liver disease due to HCV infection is still under investigation [23] .…”

Section: Discussionmentioning

confidence: 99%

Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

Korah

El-Sayed²,

El-Shafie³

et al. 2013

WJH

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“…Serum leptin was found to be higher in patients with cirrhosis during the course of chronic viral hepatitis (20 due to chronic hepatitis B and 15 due to CHC) (116). Moreover, another study showed a significant association between serum leptin and fibrosis stage in HCV-and hepatitis B virus-infected patients (117).…”

Section: Leptin In Chronic Hepatitismentioning

confidence: 96%

Potential Role of Leptin, Adiponectin and Three Novel Adipokines—Visfatin, Chemerin and Vaspin—in Chronic Hepatitis

Kukla

Mazur

Bułdak

et al. 2011

Mol Med

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Chronic hepatitis C (CHC) is generally a slowly progressive disease, but some factors associated with rapid progression have been identified. Steatosis, independently of its metabolic or viral origin, leads to liver injury and fibrosis. It is suggested that hepatitis C virus may contribute to a wide spectrum of metabolic disturbances-namely, steatosis, insulin resistance, increased prevalence of impaired glucose tolerance, type 2 diabetes mellitus and lipid metabolism abnormalities. Adipokines, which are produced mainly by adipose tissue, may influence the inflammatory response and insulin sensitivity and contribute to the development of metabolic abnormalities in CHC and also regulate fibrogenesis and angiogenesis. Visfatin was described as an adipokine with immunomodulating and proinflammatory properties that promotes B-cell maturation and enhances activation of leukocytes, synthesis of adhesion molecules and production of proinflammatory cytokines. Visfatin exerts insulin-mimetic effects, decreases plasma glucose levels and regulates cell energy balance. Chemerin stimulates chemotaxis of dendritic cells, macrophages and natural killer (NK) cells toward the site of inflammation. On the other hand, it inhibits synthesis of proinflammatory mediators and enhances adiponectin production, influences adipocyte differentiation and maturation and regulates glucose uptake in adipocytes. Vaspin expression in human adipose tissue seems to be a compensatory mechanism associated with obesity and insulin resistance. Vaspin suppresses leptin, tumor necrosis factor (TNF)-α and resistin expression. Leptin protects against liver steatosis but accelerates fibrosis progression and exacerbates the inflammatory process. In contrast, adiponectin exerts a hepatoprotective effect. In this report, data indicating a possible role of these adipokines in the pathogenesis of chronic hepatitis are summarized.

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“…Although a high incidence of hyperleptinemia has been observed in HCV infected patients with liver steatosis [22], the underlying mechanism promoting this effect remains undefined. Leptin may increase insulin resistance and fatty acid concentrations in the liver, leading to enhanced lipid peroxidation and promoting steatosis.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin and plasma ghrelin concentrations in patients with chronic hepatitis C virus with steatosis: Their effect on the response to antiviral therapy

Badawy¹,

Elmasry²,

Alenezy³

et al. 2014

IOSRJDMS

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An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study

Cited by 42 publications

References 41 publications

Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

Potential Role of Leptin, Adiponectin and Three Novel Adipokines—Visfatin, Chemerin and Vaspin—in Chronic Hepatitis

Serum leptin and plasma ghrelin concentrations in patients with chronic hepatitis C virus with steatosis: Their effect on the response to antiviral therapy

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