An assessment of the ameliorative role of hesperidin in Drosophila melanogaster model of cadmium chloride-induced toxicity

Asejeje, Folake Olubukola; Ogunro, Olalekan Bukunmi; Asejeje, Gbolahan Iyiola; Adewumi, Olumuyiwa Sunday; Abolaji, Amos O.

doi:10.1016/j.cbpc.2022.109500

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…The fly survival data suggests that D. melanogaster demonstrated a dose and time dependent response to different concentrations of Cr(VI). This could be due to increased metal accumulation in the flies as a similar trend was observed in fly survival studies by Asejeje et al (2023) using cadmium for a period of 25 days. The findings of the present study are also in accordance with the results obtained in D. melanogaster larvae exposed to cadmium (Yang et al, 2022).…”

Section: Resultssupporting

confidence: 73%

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Alleviation of hexavalent chromium induced oxidative stress in Drosophila melanogaster using leaf extracts of Moringa oleifera and Bacopa monnieri

Kurella,

Venkataramanaiah,

Narayanappa

et al. 2024

JEB

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Aim: The present study assessed the potential of Moringa oleifera and Bacopa monnieri leaf extracts in amelioration of Cr (VI) induced oxidative stress in Drosophila melanogaster. Methodology: The 96 hr lethal dose (LD50) of chromium was determined by exposing flies to varied doses (10, 20, 30,40,50,60 mg kg-1) of Cr (VI) through diet. Later, flies were exposed to 0, 30 and 50 mg kg-1 of Cr and treated with leaf extracts to evaluate their alleviating effect on lipid peroxidation, catalase and glutathione-S-transferase. In silico studies analyzed the binding pattern of potential bioactive compounds in leaf extracts to the proposed target proteins. Results: LD50 was 50 mg kg-1 obtained through. The lipid peroxidation increased 2 folds with increase in Cr (VI), however, on treatment concentration with leaf extracts it decreased 1.5 times. While glutathione-s-transferase activity was reduced by 50% in Cr (VI) treated flies, the activity significantly increased by 66% and 76% after treatment with Bacopa and Moringa leaf extracts. Catalase activity showed 50% decrease in the flies treated with Cr (VI), while combined treatment of Cr (VI) and leaf extracts showed a significant increase (1.5 times) in catalase activity suggesting recovery. Molecular docking studies on the active phytochemicals of leaf extracts demonstrated their antioxidant potential on par with taurine (ligand), a known antioxidant. Interpretation: The leaf extracts significantly alleviated the Cr (VI) induced oxidative stress, promising a natural therapy to overcome the harmful effects of Cr (VI) exposure in life forms. Key words: Bacopa monneiri, Chromium toxicity, Drosophila melanogaster, Moringa oleifera, Oxidative stress

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Section: Resultssupporting

confidence: 73%

“…4). This is similar to that observed in case of hesperidin treatment in D. melanogaster exposed to cadmium (Asejeje et al, 2023). The production of protein carbonyls indicates structural deformation in protein essential for the survival of flies.…”

Section: Total Polyphenol Contentsupporting

confidence: 87%

Alleviation of hexavalent chromium induced oxidative stress in Drosophila melanogaster using leaf extracts of Moringa oleifera and Bacopa monnieri

Kurella,

Venkataramanaiah,

Narayanappa

et al. 2024

JEB

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“…Several studies have highlighted the advantages of antioxidant supplementation for the treatment of oxidative stress-induced male infertility, where the resulting DNA damage was significantly reduced and sperm parameters were remarkably improved [ 45 , 46 , 47 ]. Notably, several previous in vivo studies have pointed to the protective effects of natural nutraceutical antioxidants, including plant derived flavonoids, against cadmium-induced testicular OS, inflammation, apoptosis and/or autophagy [ 48 , 49 , 50 ]. Similar protective effects of natural flavonoids have been reported against testicular toxicity induced by other heavy metals [ 51 , 52 , 53 , 54 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

The Palliative and Antioxidant Effects of Hesperidin against Lead-Acetate-Induced Testicular Injury in Male Wistar Rats

Abu-Khudir,

Almutairi,

Abd El-Rahman

et al. 2023

Biomedicines

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Lead (Pb)-induced reprotoxicity is a detrimental consequence of Pb exposure, which results in abnormal spermatogenesis, testicular degeneration, and pathogenic sperm changes. The association between impaired male reproductive function and Pb-induced oxidative stress (OS) has been demonstrated, with consequent testicular antioxidant deficiency. The current study investigated the protective role of the natural antioxidant hesperidin (HSD) against lead-acetate (PbAc)-induced testicular toxicity. Male Wistar rats (n = 40) were randomly divided into four experimental groups: Group I (negative control) received 2.0 mL/kg BW 0.9% saline; Group II received 100 mg/kg BW PbAc; Group III received 100 mg/kg BW HSD; and Group IV received HSD two hours before PbAc using the abovementioned doses. The treatments were administered daily for 30 consecutive days. The results showed that HSD treatment significantly restored PbAc-induced decrease in body, epididymal, and testicular weights as well as in semen parameters, reproductive hormones, and testicular markers of OS. Reduced MDA levels and improved testicular histopathological findings were also observed. Collectively, this study sheds light on the preventive role of HSD against PbAc-induced testicular injury, which is mediated via the suppression of OS and the modulation of reproductive hormones as well as the plausibility of HSD being used as a supplementary therapeutic option for recovery.

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Hesperetin-7-rutinoside mitigates erythrocyte dyslipidemia and oxidative stress induced by dichlorvos

Akamo,

Ojelabi,

Akamo

et al. 2024

Journal of Hazardous Materials Advances

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An assessment of the ameliorative role of hesperidin in Drosophila melanogaster model of cadmium chloride-induced toxicity

Cited by 7 publications

References 48 publications

Alleviation of hexavalent chromium induced oxidative stress in Drosophila melanogaster using leaf extracts of Moringa oleifera and Bacopa monnieri

Alleviation of hexavalent chromium induced oxidative stress in Drosophila melanogaster using leaf extracts of Moringa oleifera and Bacopa monnieri

The Palliative and Antioxidant Effects of Hesperidin against Lead-Acetate-Induced Testicular Injury in Male Wistar Rats

Hesperetin-7-rutinoside mitigates erythrocyte dyslipidemia and oxidative stress induced by dichlorvos

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