An assessment of the developmental toxicity of inorganic arsenic

DeSesso, John M.; Jacobson, CatherineF; Scialli, AnthonyR; Farr, CraigH; Holson, Joseph F.

doi:10.1016/s0890-6238(98)00021-5

Cited by 153 publications

(18 citation statements)

References 110 publications

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“…Chronic exposure to iAs may result in cutaneous, developmental, hematologic, reproductive, and vascular effects (Table 1) [U.S. Agency for Toxic Substances and Disease Registry (ATSDR) 2000; NRC 1999; WHO 2001]. However, the potential for iAs to cause specific birth anomalies such as neural tube defects has been questioned (DeSesso et al 1998). …”

Section: Arsenic Toxicitymentioning

confidence: 99%

Biomarkers of Exposure: A Case Study with Inorganic Arsenic

Hughes

2006

Environ Health Perspect

248

150

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The environmental contaminant inorganic arsenic (iAs) is a human toxicant and carcinogen. Most mammals metabolize iAs by reducing it to trivalency, followed by oxidative methylation to pentavalency. iAs and its methylated metabolites are primarily excreted in urine within 4–5 days by most species and have a relatively low rate of bioaccumulation. Intra- and interindividual differences in the methylation of iAs may affect the adverse health effects of arsenic. Both inorganic and organic trivalent arsenicals are more potent toxicants than pentavalent forms. Several mechanisms of action have been proposed for arsenic-induced toxicity, but a scientific consensus has not been achieved. Biomarkers of exposure may be used to quantify exposure to iAs. The most common biomarker of exposure for iAs is the measurement of total urinary arsenic. However, consumption of seafood containing high concentrations of organic arsenic can confound estimation of iAs exposure. Because these organic species are thought to be relatively nontoxic, their presence in urine may not represent increased risk. Speciation of urinary arsenic into inorganic and organic forms, and even oxidation state, gives a more definitive indication of the exposure to iAs. Questions still remain, however, as to how reliably the measurement of urinary arsenic, either total or speciated, may predict arsenic concentrations at target tissues as well as how this measurement could be used to assess chronic exposures to iAs.

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Section: Arsenic Toxicitymentioning

confidence: 99%

Biomarkers of Exposure: A Case Study with Inorganic Arsenic

Hughes

2006

Environ Health Perspect

248

150

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“…The normal range for As in the soils of various countries was found to be 0.1 to 40 mg/kg (mean of 6 mg/kg) [ 14 ]. Desesso, et al [ 15 ] indicated that As was likely to pose a risk to pregnant women and their offspring when soil As concentration was more than 100 mg/kg. The guideline for maximum recommended Cd intake set by WHO [ 16 ] and the United States Environmental Protection Agency (US EPA) [ 17 ] is 1 μg/(kg body weight·d).…”

Section: Introductionmentioning

confidence: 99%

Integrated Health Risk Assessment of Heavy Metals in Suxian County, South China

Song

Zhuang

Jiang

et al. 2015

IJERPH

106

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The purpose of this study was to assess soil heavy metal contamination and the potential risk for local residents in Suxian county of Hunan Province, southern China. Soil, rice and vegetable samples from the areas near the mining industrial districts were sampled and analyzed. The results indicate that the anthropogenic mining activities have caused local agricultural soil contamination with As, Pb, Cu and Cd in the ranges of 8.47–341.33 mg/kg, 19.91–837.52 mg/kg, 8.41–148.73 mg/kg and 0.35–6.47 mg/kg, respectively. GIS-based mapping shows that soil heavy metal concentrations abruptly diminish with increasing distance from the polluting source. The concentrations of As, Pb, Cu and Cd found in rice were in the ranges of 0.02–1.48 mg/kg, 0.66–5.78 mg/kg, 0.09–6.75 mg/kg, and up to 1.39 mg/kg, respectively. Most of these concentrations exceed their maximum permissible levels for contaminants in foods in China. Heavy metals accumulate to significantly different levels between leafy vegetables and non-leafy vegetables. Food consumption and soil ingestion exposure are the two routes that contribute to the average daily intake dose of heavy metals for local adults. Moreover, the total hazard indices of As, Pb and Cd are greater than or close to the safety threshold of 1. Long-term As, Pb and Cd exposure through the regular consumption of the soil, rice and vegetables in the investigated area poses potential health problems to residents in the vicinity of the mining industry.

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“…Adverse health effects associated with chronic exposure to As-contaminated water include skin, bladder, kidney, and liver cancers, diabetes, and hypertension [National Research Council (NRC) 1999]. Reports in the literature suggest that inorganic As (InAs) also poses increased reproductive and developmental risks in animals, though few human studies have focused on these outcomes (DeSesso et al 1998; Waalkes et al 2004). Relatively little is known about transplacental transfer of As.…”

mentioning

confidence: 99%

Determinants of Arsenic Metabolism: Blood Arsenic Metabolites, Plasma Folate, Cobalamin, and Homocysteine Concentrations in Maternal–Newborn Pairs

Hall

Gamble

Slavkovich

et al. 2007

Environ Health Perspect

158

119

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BackgroundIn Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized.ObjectivesWe therefore conducted a study of 101 pregnant women who gave birth in Matlab, Bangladesh.MethodsMaternal and cord blood pairs were collected and concentrations of total As were analyzed for 101 pairs, and As metabolites for 30 pairs. Maternal urinary As metabolites and plasma folate, cobalamin, and homocysteine levels in maternal cord pairs were also measured. Household tube well–water As concentrations exceeded the World Health Organization guideline of 10 μg/L in 38% of the cases.ResultsWe observed strong associations between maternal and cord blood concentrations of total As (r = 0.93, p < 0.0001). Maternal and cord blood arsenic metabolites (n = 30) were also strongly correlated: in dimethylarsinate (DMA) (r = 0.94, p < 0.0001), monomethylarsonate (r = 0.80, p < 0.0001), arsenite (As+3) (r = 0.80, p < 0.0001), and arsenate (As+5) (r = 0.89, p < 0.0001). Maternal homocysteine was a strong predictor of %DMA in maternal urine, maternal blood, and cord blood (β = −6.2, p < 0.02; β = −10.9, p < 0.04; and β = −13.7, p < 0.04, respectively). Maternal folate was inversely associated with maternal blood As5+ (β = 0.56, p < 0.05), and maternal cobalamin was inversely associated with cord blood As5+ (β = −1.2, p < 0.01).ConclusionsWe conclude that exposure to all metabolites of inorganic As occurs in the prenatal period.

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An assessment of the developmental toxicity of inorganic arsenic

Cited by 153 publications

References 110 publications

Biomarkers of Exposure: A Case Study with Inorganic Arsenic

Biomarkers of Exposure: A Case Study with Inorganic Arsenic

Integrated Health Risk Assessment of Heavy Metals in Suxian County, South China

Determinants of Arsenic Metabolism: Blood Arsenic Metabolites, Plasma Folate, Cobalamin, and Homocysteine Concentrations in Maternal–Newborn Pairs

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