1982
DOI: 10.1111/j.1476-5381.1982.tb09254.x
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An Assessment of the Effectiveness of Neonatal Treatment With Guanethidine as a Means of Producing Sympathectomy

Abstract: 1 Male Wistar rats were treated neonatally with guanethidine (following a protocol reported to produce a permanent peripheral sympathectomy) and the extent of the sympathectomy was assessed when the rats were mature.2 The noradrenaline content of right and left atria and the ventricles was markedly reduced in 9-and 26-week old rats which had been treated with guanethidine. The extent of depletion in the ventricles was similar at both times but the atrial content increased between 9 and 26 weeks.3 Arterial bloo… Show more

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Cited by 13 publications
(5 citation statements)
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“…Although we accept that the systolic blood pressure recorded by the tail-cuff method may not always truly represent systemic arterial blood pressure in guanethidine-treated rats (see above), it is clear from the second part of our investigation that the failure to demonstrate isolation-induced hypertension in those animals was not due to the method of blood pressure measurement since, when blood pressures were measured directly, the control, isolated rats were hypertensive whereas the guanethidine-treated rats were not. Within each group of rats that had received guanethidine, there were some animals which did show slight increases in blood pressure after isolation; this finding bears out our previous observations [5] of a variation between different animals in the extent of damage to the noradrenergic nerves.…”
Section: Discussionsupporting
confidence: 69%
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“…Although we accept that the systolic blood pressure recorded by the tail-cuff method may not always truly represent systemic arterial blood pressure in guanethidine-treated rats (see above), it is clear from the second part of our investigation that the failure to demonstrate isolation-induced hypertension in those animals was not due to the method of blood pressure measurement since, when blood pressures were measured directly, the control, isolated rats were hypertensive whereas the guanethidine-treated rats were not. Within each group of rats that had received guanethidine, there were some animals which did show slight increases in blood pressure after isolation; this finding bears out our previous observations [5] of a variation between different animals in the extent of damage to the noradrenergic nerves.…”
Section: Discussionsupporting
confidence: 69%
“…Furthermore, when systolic blood pressures were recordable they were found to be lower in group-housed guanethidine-treated rats than in control animals (see the Results section); this was not the case in our earlier experiments in which arterial blood pressures were measured directly [5]. For these reasons the experiment was repeated and, at the end of the period of isolation, arterial blood pressures were measured directly.…”
Section: Blood Pressuresmentioning
confidence: 81%
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“…The release of AD from the adrenal glands during the presssor response to ANG II may contribute to blood pressure regulation due to enhanced adrenoceptor responsiveness. Some investigators have sug¬ gested that adrenal medullary hyperactivity sustains blood pressure in the absence of an intact sympathetic nervous system in conscious rats (Bennett et al 1982). How¬ ever, there is little evidence of a significant role for adrenal catecholamine release in the pressor response to physiological levels of ANG II in vivo.…”
Section: Ang Ii-mediated Release Of Catecholaminesmentioning
confidence: 98%
“…It is generally accepted that guanethidine, a noradrenergic neurone blocking agent, destroys peripheral sympathetic nerves when administered chronically to newborn rats in high doses (Mills et al 1986), possibly via an immune-mediated mechanism (Manning et al 1983). There are few data in the literature regarding plasma catecholamine levels following guanethidine treatment; the catecholamine contents in sympathetically innervated tissues are usually used as a measure of chemical sympathectomy in rats (Johnson et al 1976, Bennett et al 1982, Julien et al 1989, Lo et al 1991.…”
Section: Introductionmentioning
confidence: 99%