2019
DOI: 10.1002/bmc.4469
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An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC–QTOF–MS method

Abstract: Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co‐administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK‐4/6 primarily metabolized by CYP3A enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague–Dawley rats, a rapid and sensitive UHPLC–QTOF–MS method was established. Chromatographi… Show more

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Cited by 10 publications
(3 citation statements)
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“…Smith et al introduced the use of an automated micro-sample processing for the pretreatment of mouse plasma samples prior to LC-MS/MS analysis of palbociclib; however, the availability of this system is restricted in many laboratories [9]. Recently, Paul et al described two bioanalytical methods for the quantification of palbociclib in rat plasma using an LC-MS method using a high-resolution quadrupole time of flight (Q-TOF) mass spectrometer, which is more convenient for qualitative rather than quantitative assays; therefore, the instrumentation is restricted in most bioanalytical laboratories [10, 11]. For ribociclib, two bioanalytical assays have been published.…”
Section: Introductionmentioning
confidence: 99%
“…Smith et al introduced the use of an automated micro-sample processing for the pretreatment of mouse plasma samples prior to LC-MS/MS analysis of palbociclib; however, the availability of this system is restricted in many laboratories [9]. Recently, Paul et al described two bioanalytical methods for the quantification of palbociclib in rat plasma using an LC-MS method using a high-resolution quadrupole time of flight (Q-TOF) mass spectrometer, which is more convenient for qualitative rather than quantitative assays; therefore, the instrumentation is restricted in most bioanalytical laboratories [10, 11]. For ribociclib, two bioanalytical assays have been published.…”
Section: Introductionmentioning
confidence: 99%
“…Finally, the method we developed is one of the first in the literature for the routine measurement of PALBO in human plasma using a mass spectrometry detection. Indeed, the methods described until now either concerned studies on animals, [32][33][34][35] or measurement in plasma with UV detection [36]. Only two very recent articles describe methods for the measurement of PALBO in human with mass spectrometry detection [37,38].…”
Section: Discussionmentioning
confidence: 99%
“…The molecular docking studies are useful for determining the binding capacity of drug molecules and their DPs towards the corresponding protein. Supported extensive literature search, LC-MS-MS [12][13][14][15][16][17][18][19] and LC techniques 20 were reported for therapeutic drug monitoring investigations in humans, animals and Pharmaceutical formulations. Hence, no method reported thus far for the characterization of Palbociclib together with DPs.…”
Section: Introductionmentioning
confidence: 99%