An assessment of the interactions between diclofenac sodium and ammonio methacrylate copolymer using thermal analysis and Raman spectroscopy

Sipos, Péter; Szücs, Mária; Szabó, András; Erös, I.; Szabó‐Révész, Piroska

doi:10.1016/j.jpba.2007.10.008

Cited by 36 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, detailed studies on the interaction of the quaternary ammonium polycations-Eudragit R RS copolymers by means of ionic bond formation with DS were reported. 51 Similar interactions can be assumed to have happened in our case too, which dramatically sustained DS release from PM matrix. The obtained results are in a good agreement with the swelling properties of PMs: low swelling behavior and comparatively high erosion of these matrices in GI conditions.…”

Section: Drug Release From Poly(meth)acrylate Matricessupporting

confidence: 66%

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Moustafine

Bobyleva

Bukhovets

et al. 2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Drug Release From Poly(meth)acrylate Matricessupporting

confidence: 66%

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Moustafine

Bobyleva

Bukhovets

et al. 2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Differential scanning calorimetry and thermogravimetric analysis are used to investigate the dispersed/ dissolved state of DCF in preparation of diclofenac sodium and the water-insoluble ammonio methacrylate copolymer, the thermal stability and the properties of the films of this mixture were confirmed. Raman spectroscopy corroborates the possible interactions between the two products [14].…”

Section: Introductionsupporting

confidence: 60%

Study of Antiviral Diclofenac by Surface-Enhanced Raman Spectroscopy

Ros¹

2017

J Pharma Care Health Sys

View full text Add to dashboard Cite

Diclofenac is a medication that presents in its structure two benzene rings joined by an amine group presenting: The first ring two chlorine atoms, both in the ortho position with respect to the amino group and the second ring is bound to ethanoic acid, also in ortho position with respect to this amino group, thus showing the carboxylate group (COO-).We have studied the Raman spectrum of solid Diclofenac (DCF), their spectra in solution in methanol at different concentrations and Surface-Enhanced Raman Spectroscopy (SERS) with additives that increase the profile of spectra. The interaction of this molecule with Ag (that is in the colloid used in SERS), is significant on the two rings, the COO-and amine group and Cl atom and C 7 H 2 group, everyone in the structure of DCF.

show abstract

“…On the other hand, the addition of a cosolvent could increase the microsphere porosity, leading to drug loss during the preparation and therefore a lower EE [34]. On the basis of preliminary studies [35] the used drug/copolymer ratios can ensure the molecular dispersion of drug in the copolymer matrix.…”

Section: Resultsmentioning

confidence: 99%

Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio

et al. 2011

Self Cite

View full text Add to dashboard Cite

The objectives of this work were the formulation optimization of the preparation process parameters and to evaluate spray-dried sustained-release microspheres using ammonio methacrylate copolymer (AMC) as a polymer matrix. The effects of log P and the concentrations of the cosolvents (acetone, methyl ethyl ketone and n-butyl acetate) and different drug/copolymer ratios as independent variables on the physicochemical parameters (the W1/O emulsion viscosity, the microsphere production yield, the average particle size, the encapsulation efficiency) and the cumulative in vitro drug release as dependent variables were studied. The optimization was carried out on the basis of the 33 factorial design study. The optimization process results showed that addition of polar cosolvents proved effective, linear relationships were observed between the independent and the dependent variables. The best conditions were achieved by microspheres prepared by using a low/medium cosolvent log P, cosolvent concentration of 25–50% v/v and a drug/copolymer ratio of 1:16. The microspheres ensured sustained release with Nernst and Baker-Lonsdale release profiles.

show abstract

An assessment of the interactions between diclofenac sodium and ammonio methacrylate copolymer using thermal analysis and Raman spectroscopy

Cited by 36 publications

References 32 publications

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55)

Study of Antiviral Diclofenac by Surface-Enhanced Raman Spectroscopy

Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio

Contact Info

Product

Resources

About