An assessment of the risk, cost‐effectiveness, and perceived benefits of anti‐parvovirus B19 tested blood products

Hoeven, Loan R. van; Janssen, Mart P.; Lieshout‐Krikke, Ryanne W.; Backer, Marijke W. Molenaar‐de

doi:10.1111/trf.15324

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Eight studies reported a selection method that used convenience sampling in which experts were selected due to their proximity to the study team. 39,45,46,49,51,59,68,69 Of the remaining studies, 4 used publication records, 13,14,64,66 2 used prescribing records to identify clinicians who have used the medications being evaluated, 67,71 2 consulted external advisors, 52,58 and the rest used snowball sampling, 64,70 trial involvement, 12 all certified obstetricians/gynecologists in the country of study with years of experience, 55 or international reputation. 61 The average number of experts recruited per EE was 11, with a range of 1 to 30.…”

Section: Resultsmentioning

confidence: 99%

“…The most frequent methods were Delphi or modified Delphi process ( n = 10), 13,36,37,41,42,47,55,58,61,66 while 2 used the SHELF method 63,64 ; both methods rely on multiple rounds of discussion to build consensus among experts. Elicitations were frequently done virtually or over the phone ( n = 13) 14,36,41,46,48,50,53,55,57,66,67,70,71 while only 5 specified that the elicitation was conducted in person. 38,39,48,51,60 Web- or spreadsheet-based elicitation tools were used to facilitate data collection in 9 elicitations.…”

Section: Resultsmentioning

confidence: 99%

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The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review

et al. 2021

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Background Expert elicitation (EE) has been used across disciplines to estimate input parameters for computational modeling research when information is sparse or conflictual. Objectives We conducted a systematic review to compare EE methods used to generate model input parameters in health research. Data Sources PubMed and Web of Science. Study Eligibility Modeling studies that reported the use of EE as the source for model input probabilities were included if they were published in English before June 2021 and reported health outcomes. Data Abstraction and Synthesis Studies were classified as “formal” EE methods if they explicitly reported details of their elicitation process. Those that stated use of expert opinion but provided limited information were classified as “indeterminate” methods. In both groups, we abstracted citation details, study design, modeling methodology, a description of elicited parameters, and elicitation methods. Comparisons were made between elicitation methods. Study Appraisal Studies that conducted a formal EE were appraised on the reporting quality of the EE. Quality appraisal was not conducted for studies of indeterminate methods. Results The search identified 1520 articles, of which 152 were included. Of the included studies, 40 were classified as formal EE and 112 as indeterminate methods. Most studies were cost-effectiveness analyses (77.6%). Forty-seven indeterminate method studies provided no information on methods for generating estimates. Among formal EEs, the average reporting quality score was 9 out of 16. Limitations Elicitations on nonhealth topics and those reported in the gray literature were not included. Conclusions We found poor reporting of EE methods used in modeling studies, making it difficult to discern meaningful differences in approaches. Improved quality standards for EEs would improve the validity and replicability of computational models. Highlights We find extensive use of expert elicitation for the development of model input parameters, but most studies do not provide adequate details of their elicitation methods. Lack of reporting hinders greater discussion of the merits and challenges of using expert elicitation for model input parameter development. There is a need to establish expert elicitation best practices and reporting guidelines.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review

et al. 2021

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“…Their results revealed a mean of 18.2 infected blood products per year (0.004% of erythrocyte concentrates and 0.03% of thrombocyte concentrate). They concluded that 5.33 infections could be prevented by that screening annually 45 . However, it needs to be considered that these numbers are difficult to compare between different countries due to regional and also seasonal outbreaks.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that 5.33 infections could be prevented by that screening annually. 45 However, it needs to be considered that these numbers are difficult to compare between different countries due to regional and also seasonal outbreaks. 46 In Germany, between 1997 and 2017, there has been no single case of a transfusion-associated B19V infection reported to the Paul-Ehrlich Institute, supporting the absence of a general recommendation for a blood product screening of B19V in Germany.…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 infection in pediatric allogeneic hematopoietic cell transplantation – Single‐center experience and review

Holterhus

Hennies

Hillmann

et al. 2023

Transplant Infectious Dis

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Background Parvovirus B19 (B19V) infection following pediatric hematopoietic cell transplantation (HCT) is a rare complication and available data is scarce. Therefore, we present the experience with B19V Infection in allogeneic pediatric HCT recipients at our transplant center together with a systematic review of the literature. Methods Pediatric HCT patients with Parvovirus B19 infection treated at the University Children's Hospital Münster between 1999 and 2021 were retrospectively identified and clinical data were analyzed. Additionally, a systematic MEDLINE search to identify relevant articles was performed. Results We identified three out of 445 patients (0.6%) with B19V infection post‐transplantation. B19V infection occurred in combination with other complications like Graft‐versus‐Host disease, additional infections, or autoimmune‐mediated hemolysis potentially triggered by B19V. In one patient these complications lead to a fatal outcome. The review of the literature showed considerable morbidity of B19V infection with the potential for life‐threatening complications. Most patients were treated by red blood cell transfusion and intravenous immunoglobulins (IVIG) with a high succession rate. Conclusion Symptomatic B19V infection following HCT remains a rare but potentially challenging complication. A causal antiviral therapy does not exist as well as general recommendations on dosage and duration of IVIG therapy. Despite this, most patients are treated successfully with these measures. Additionally, transmission via blood or stem cell products is also rare and no general recommendations on B19V screenings exist.

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Transfusion‐Transmitted Diseases

McCullough

2021

Transfusion Medicine

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An assessment of the risk, cost‐effectiveness, and perceived benefits of anti‐parvovirus B19 tested blood products

Cited by 5 publications

References 29 publications

The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review

The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review

Parvovirus B19 infection in pediatric allogeneic hematopoietic cell transplantation – Single‐center experience and review

Transfusion‐Transmitted Diseases

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