An assessment of toll-like receptor 7 and 8 gene polymorphisms with susceptibility to HIV-1 infection, AIDS development and response to antiretroviral therapy

Zaidane, Imane; Ouladlahsen, A.; Bensghir, Rajaa; Chihab, Hajar; Jadid, Fatima Zahra; fɩhry, Raouia El; Baba, Hanâ; Filali, Kamal Marhoum El; Oudghiri, Mounia; Wakrim, Lahcen; Benjelloun, Soumaya

doi:10.1016/j.imlet.2020.08.008

Cited by 5 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most frequent TLR8 polymorphism, TLR8 A1G (rs3764880), has been reported to confer protection against HIV progression, suggesting the role of TLR8 in infection [101]. Another study assessed TLR7 and eight gene polymorphisms associated with susceptibility to HIV-1 infection and found that TLR8 polymorphisms could affect HIV-1 infection [102]. TLR7 IVS2-151-A and TLR8 Met alleles affect plasma HIV viral loads [102].…”

Section: Tlr Response To Human Immunodeficiency Virus (Hiv) Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Toll-like Receptor Response to Human Immunodeficiency Virus Type 1 or Co-Infection with Hepatitis B or C Virus: An Overview

Kayesh

Kohara

Tsukiyama-Kohara

2023

IJMS

View full text Add to dashboard Cite

Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors that play important roles in the early detection of pathogen-associated molecular patterns and shaping innate and adaptive immune responses, which may influence the consequences of infection. Similarly to other viral infections, human immunodeficiency virus type 1 (HIV-1) also modulates the host TLR response; therefore, a proper understanding of the response induced by human HIV-1 or co-infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), due to the common mode of transmission of these viruses, is essential for understanding HIV-1 pathogenesis during mono- or co-infection with HBV or HCV, as well as for HIV-1 cure strategies. In this review, we discuss the host TLR response during HIV-1 infection and the innate immune evasion mechanisms adopted by HIV-1 for infection establishment. We also examine changes in the host TLR response during HIV-1 co-infection with HBV or HCV; however, this type of study is extremely scarce. Moreover, we discuss studies investigating TLR agonists as latency-reverting agents and immune stimulators towards new strategies for curing HIV. This understanding will help develop a new strategy for curing HIV-1 mono-infection or co-infection with HBV or HCV.

show abstract

Section: Tlr Response To Human Immunodeficiency Virus (Hiv) Infectionmentioning

confidence: 99%

“…Another study assessed TLR7 and eight gene polymorphisms associated with susceptibility to HIV-1 infection and found that TLR8 polymorphisms could affect HIV-1 infection [102]. TLR7 IVS2-151-A and TLR8 Met alleles affect plasma HIV viral loads [102].…”

Section: Tlr Response To Human Immunodeficiency Virus (Hiv) Infectionmentioning

confidence: 99%